The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.

The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.

Protein ubiquitination is a post-translational protein modification that regulates many biological conditions. Trip12 is a HECT-type E3 ubiquitin ligase that ubiquitinates ARF and APP-BP1. However, the significance of Trip12 in vivo is largely unknown. Here we show that the ubiquitin ligase activity...

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Bibliographic Details
Main Authors: Masashi Kajiro, Mai Tsuchiya, Yoh-Ichi Kawabe, Ryohei Furumai, Naoya Iwasaki, Yuki Hayashi, Miyuki Katano, Yuka Nakajima, Natsuka Goto, Tatsuya Watanabe, Akiko Murayama, Hisashi Oishi, Masatsugu Ema, Satoru Takahashi, Hiroyuki Kishimoto, Junn Yanagisawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3196520?pdf=render

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