Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration[S]

Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration[S]

Retinal degeneration (RD) affects millions of people and is a major cause of ocular impairment and blindness. With a wide range of mutations and conditions leading to degeneration, targeting downstream processes is necessary for developing effective treatments. Ceramide and sphingosine-1-phosphate,...

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Bibliographic Details
Main Authors: Megan Stiles, Hui Qi, Eleanor Sun, Jeremy Tan, Hunter Porter, Jeremy Allegood, Charles E. Chalfant, Douglas Yasumura, Michael T. Matthes, Matthew M. LaVail, Nawajes A. Mandal
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Journal of Lipid Research
Subjects:
retina
P23H line 1 rats
photoreceptors
apoptosis
ceramide
hexosyl-ceramide
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309858

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http://www.sciencedirect.com/science/article/pii/S0022227520309858

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