Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane proximal region with nearly pan-isolate neutraliz...

Full description

Bibliographic Details
Main Authors:	James J. Steinhardt, Javier Guenaga, Hannah L. Turner, Krisha McKee, Mark K. Louder, Sijy O’Dell, Chi-I Chiang, Lin Lei, Andrey Galkin, Alexander K. Andrianov, Nicole A. Doria-Rose, Robert T. Bailer, Andrew B. Ward, John R. Mascola, Yuxing Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03335-4

Similar Items

Isolation of broadly neutralizing HIV-1 antibodies from high-throughput single B cell culture
by: Longo NS, et al.
Published: (2012-09-01)

HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization.
by: Marjon Navis, et al.
Published: (2014-08-01)

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.
by: Rosemarie D Mason, et al.
Published: (2016-04-01)

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.
by: Rosemarie D Mason, et al.
Published: (2016-05-01)

OA05-05. Impact of <it>in vivo </it>CD4 binding during HIV-1 Env trimer immunizations of rhesus macaques
by: Wyatt RT, et al.
Published: (2009-10-01)

Dual Antigen-Restricted Complementation of a Two-Part Trispecific Antibody for Targeted Immunotherapy of Blood Cancer
by: Banaszek, Agnes
Published: (2013)

A Trispecific Anti-HIV Chimeric Antigen Receptor Containing the CCR5 N-Terminal Region
by: Agnes Hajduczki, et al.
Published: (2020-05-01)

Analysis of [Gossypium capitis-viridis × (G.hirsutum × G.australe)2] Trispecific Hybrid and Selected Characteristics.
by: Di Chen, et al.
Published: (2015-01-01)

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
by: Yen-Ting Lai, et al.
Published: (2019-01-01)

Effect of GammaRay in the Progeny of Trispecific Hybrid [(Gossypium hirsutum x G. raimondii)² x G. sturtianum]
by: Fatimata Bintou Hassedine DIOUF, et al.
Published: (2010-09-01)

Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
by: Cheng Zhu, et al.
Published: (2019-02-01)

Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy
by: Guangsheng Pei, et al.
Published: (2021-07-01)

Exploitation of trispecific hybrids to introgress the glandless seed and glanded plant trait of Gossypium sturtianum Willis into G. hirsutum L.
by: Jean-Pierre Baudoin, et al.
Published: (1997-01-01)

Safety and Immunogenicity of a rAd35-EnvA Prototype HIV-1 Vaccine in Combination with rAd5-EnvA in Healthy Adults (VRC 012).
by: Michelle C Crank, et al.
Published: (2016-01-01)

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design
by: Shailendra Kumar Sharma, et al.
Published: (2015-04-01)

Trispecific killer engager 161519 enhances natural killer cell function and provides anti-tumor activity against CD19-positive cancers
by: Ying Cheng, et al.
Published: (2020-11-01)

Design of a Trispecific Checkpoint Inhibitor and Natural Killer Cell Engager Based on a 2 + 1 Common Light Chain Antibody Architecture
by: Jan P. Bogen, et al.
Published: (2021-05-01)

Exploiting glycan topography for computational design of Env glycoprotein antigenicity.
by: Wen-Han Yu, et al.
Published: (2018-04-01)

Exploiting glycan topography for computational design of Env glycoprotein antigenicity
by: Zhao, Peng, et al.
Published: (2018)

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.
by: Viktoriya Dubrovskaya, et al.
Published: (2017-09-01)

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice
by: Martina Soldemo, et al.
Published: (2017-11-01)

Les derniers siècles de l’époque angkorienne au Cambodge [env.1220 - env.1500]
by: Provost-Roche, Ludivine
Published: (2010)

Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission
by: María Inés Barría, et al.
Published: (2021-08-01)

EnvIRONmental Aspects in Myelodysplastic Syndrome
by: Verena Petzer, et al.
Published: (2021-05-01)

Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines
by: Bartek Nogal, et al.
Published: (2020-03-01)

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.
by: Nicole A Doria-Rose, et al.
Published: (2017-01-01)

Characterisation of the HIV-1 subtype C Env gene and the expression of the Env protein from selected isolates in mammalian cells
by: De Villiers, Tania
Published: (2012)

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.
by: Ema T Crooks, et al.
Published: (2018-05-01)

Structure and Dynamics of HIV-1 Env Trimer
by: Wang, Haoqing
Published: (2019)

Viral vector delivery of Env trimer immunogens
by: Parks CL, et al.
Published: (2012-09-01)

Analysis of transcribed human endogenous retrovirus W <it>env </it>loci clarifies the origin of multiple sclerosis-associated retrovirus <it>env </it>sequences
by: Mueller-Lantzsch Nikolaus, et al.
Published: (2009-04-01)

P04-24. Frequencies of HIV Env-specific B cells and neutralizing antibodies during DNA-prime/protein-boost immunization with three different Env immunogens*
by: Stamatatos L, et al.
Published: (2009-10-01)

Characterizing the Relationship Between Neutralization Sensitivity and env Gene Diversity During ART Suppression
by: Andrew Wilson, et al.
Published: (2021-09-01)

Novel SHIVs encoding transmitted/founder envs for latency and cure research
by: K. Bar, et al.
Published: (2017-12-01)

Structural Basis for Env Incorporation into HIV-1 Particles
by: R. Elliot Murphy, et al.
Published: (2020-07-01)

Unlocking HIV-1 Env: implications for antibody attack
by: Jonathan Richard, et al.
Published: (2017-09-01)

The role of polyproline motifs in the histidine kinase EnvZ.
by: Magdalena Motz, et al.
Published: (2018-01-01)

Env-Specific Antibodies in Chronic Infection versus in Vaccination
by: Martina Soldemo, et al.
Published: (2017-09-01)

Development of FPV's env Gene as a Subunit Vaccine
by: 王智弘
Published: (2009)

Design and Characterization of HIV-1 ENV Derived Immunogens
by: Purwar, Mansi
Published: (2018)