Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane proximal region with nearly pan-isolate neutraliz...
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Bibliographic Details
| Main Authors: |
James J. Steinhardt,
Javier Guenaga,
Hannah L. Turner,
Krisha McKee,
Mark K. Louder,
Sijy O’Dell,
Chi-I Chiang,
Lin Lei,
Andrey Galkin,
Alexander K. Andrianov,
Nicole A. Doria-Rose,
Robert T. Bailer,
Andrew B. Ward,
John R. Mascola,
Yuxing Li |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-03335-4
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