Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages

Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages

In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of the human cathelicidin CAMP in skin lesions of Ethiopian patients with cutaneous leishmaniasis. Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP)...

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Bibliographic Details
Main Authors: Peter Crauwels, Elena Bank, Bianca Walber, Ulf Alexander Wenzel, Birgitta Agerberth, Menberework Chanyalew, Markos Abebe, Renate König, Uwe Ritter, Norbert Reiling, Ger van Zandbergen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
Leishmania
human macrophages
vitamin D
cathelicidin (LL-37)
human primary immune cells
antimicrobial activity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02697/full

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