Meta-analysis of studies on the effect of vitamin D supplementation on blood glucose, lipid profile and inflammatory markers in patients with diabetes

• Main Authors: H Fallahzadeh, Z Golshanzadeh, H Mozafari, M Momayezi
• Format: Article
• Language: fas
• Published: Shahid Sadoughi University of Medical Sciences 2016-01-01
• Series: Toloo-e-behdasht
• Subjects: Vitamin D; HOMA-IR; Insulin sensitivity; Meta-analysis; Diabetes
• Online Access: http://tbj.ssu.ac.ir/browse.php?a_code=A-10-547-2&slc_lang=en&sid=1

Introduction: Vitamin D deficiency and type 2 diabetes are both common diseases. Numerous studies have examined the relationship between the two. The purpose of this study was to investigate the effect of vitamin D supplementation on glycemic status, lipid profile and inflammatory markers in patients with diabetes. Method: Type of systematic review and meta-analysis, which is actually a review on the studies available. Beginning a search extensively on electronic resources English, including EMBASE, Web of science, Medline Scopus and Who and electronic resources Persian including SID and Google scholar for diabetes-related research papers do. Result: The test of heterogeneity, studies with significant heterogeneity in vitamin D, HOMA-IR and insulin sensitivity were the random effects model was used and the mean difference and 95% confidence intervals between the two groups in the vitamin D , 1.87 and (-5.49,9.23), HOMA-IR 0.09 and (-.023,0.05) and insulin sensitivity, 0.24 and (-0.75,0.26), respectively. Discussion: The overall results of this study showed that the meta-analysis, vitamin D and insulin sensitivity in diabetic patients is effective and HOMA-IR is not effective on patients with diabetes.