Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts During ex vivo Organ Perfusion

Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts During ex vivo Organ Perfusion

Organ gene therapy represents a promising tool to correct diseases or improve graft survival after transplantation. Polymorphic variation of the major histocompatibility complex (MHC) antigens remains a major obstacle to long-term graft survival after transplantation. Previously, we demonstrated tha...

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Bibliographic Details
Main Authors: Yuliia Yuzefovych, Emilio Valdivia, Song Rong, Franziska Hack, Tamina Rother, Jessica Schmitz, Jan Hinrich Bräsen, Dirk Wedekind, Cyril Moers, Nadine Wenzel, Faikah Gueler, Rainer Blasczyk, Constanca Figueiredo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
transplantation - kidney
organ engineering
HLA
gene therapy
lentiviral vector
organ perfusion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00265/full

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