Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington’s Disease Patients

Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington’s Disease Patients

Huntington’s disease (HD) is an autosomal-dominant neurodegenerative movement disorder that presents with prominent cognitive and psychiatric dysfunction. Brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of HD, as well as other neurodegenerative and psychiatric...

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Bibliographic Details
Main Authors: Ashley Gutierrez, Jody Corey-Bloom, Elizabeth A. Thomas, Paula Desplats
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Huntington’s disease
brain-derived neurotrophic factor
DNA methylation
saliva
blood
biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00335/full

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