Chlamydia trachomatis Infection Is Associated with E-Cadherin Promoter Methylation, Downregulation of E-Cadherin Expression, and Increased Expression of Fibronectin and α-SMA—Implications for Epithelial-Mesenchymal Transition

Chlamydia trachomatis Infection Is Associated with E-Cadherin Promoter Methylation, Downregulation of E-Cadherin Expression, and Increased Expression of Fibronectin and α-SMA—Implications for Epithelial-Mesenchymal Transition

Chlamydia trachomatis (Ct) can induce scarring disease of the ocular mucosa, known as trachoma, the most common infectious cause of blindness worldwide. We hypothesized that epithelial-mesenchymal transition (EMT) contributes to the fibrotic process in trachomatous scarring. Infection of human conju...

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Bibliographic Details
Main Authors: Jovana Rajić, Aleksandra Inic-Kanada, Elisabeth Stein, Svetlana Dinić, Nadine Schuerer, Aleksandra Uskoković, Ehsan Ghasemian, Mirjana Mihailović, Melita Vidaković, Nevena Grdović, Talin Barisani-Asenbauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chlamydia trachomatis
human conjunctival epithelial cells
HCjE
epithelial-mesenchymal transition (EMT)
DNA methylation
E-cadherin
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00253/full

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