MicroRNA-545 suppresses progression of ovarian cancer through mediating PLK1 expression by a direct binding and an indirect regulation involving KDM4B-mediated demethylation

MicroRNA-545 suppresses progression of ovarian cancer through mediating PLK1 expression by a direct binding and an indirect regulation involving KDM4B-mediated demethylation

Abstract Background Ovarian cancer (OC) is a life-threatening gynecological malignancy where dysregulation of microRNAs (miRNAs) is frequently implicated. This study focuses on the function of miR-545 on OC development and the molecules involved. Methods miR-545 expression in OC tissues and cell lin...

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Bibliographic Details
Main Authors: Hailing Zhang, Ke Zhang, Zhen Xu, Zhilong Chen, Qian Wang, Chenyang Wang, Jinquan Cui
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
microRNA-545
KDM4B
PLK1
Ovarian cancer
Online Access:https://doi.org/10.1186/s12885-021-07830-8

Internet

https://doi.org/10.1186/s12885-021-07830-8

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