Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors

Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors

The role of cystatin C (Cys-C) in tumorigenesis and progression of bladder urothelial tumors (BUT) is still indefinite. We retrospectively collected the clinical information from the records of 425 BUT patients. Pretreatment serum Cys-C levels were compared across the various groups. Then we subgrou...

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Main Authors: Hui Wang, Lijian Gao, Cuiyu Meng, Nengwang Yu, Feilong Yang, Cong Zhang, Dawei Li, Lei Yan, Hainan Liu, Zhonghua Xu
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/2617439
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spelling doaj-03c408c5dcff4a2581af958d92e193902020-11-24T21:17:05ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/26174392617439Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial TumorsHui Wang0Lijian Gao1Cuiyu Meng2Nengwang Yu3Feilong Yang4Cong Zhang5Dawei Li6Lei Yan7Hainan Liu8Zhonghua Xu9Department of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of ICU, Dezhou People’s Hospital, Dezhou, Shandong Province 253000, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Urology, Qilu Hospital of Shandong University, Jinan 250012, ChinaThe role of cystatin C (Cys-C) in tumorigenesis and progression of bladder urothelial tumors (BUT) is still indefinite. We retrospectively collected the clinical information from the records of 425 BUT patients. Pretreatment serum Cys-C levels were compared across the various groups. Then we subgroup the patients with GFR ≥ 90 mg/min/1.73 m2, to exclude the effects of lower renal function on cystatin C. No statistically significant differences in the levels of serum Cys-C were found among the tumor characteristics (all P>0.05). In conclusion, circulating Cys-C was not a reliable predictor for clinicopathological characteristics of BUT patients.http://dx.doi.org/10.1155/2018/2617439
collection DOAJ
language English
format Article
sources DOAJ
author Hui Wang
Lijian Gao
Cuiyu Meng
Nengwang Yu
Feilong Yang
Cong Zhang
Dawei Li
Lei Yan
Hainan Liu
Zhonghua Xu
spellingShingle Hui Wang
Lijian Gao
Cuiyu Meng
Nengwang Yu
Feilong Yang
Cong Zhang
Dawei Li
Lei Yan
Hainan Liu
Zhonghua Xu
Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors
BioMed Research International
author_facet Hui Wang
Lijian Gao
Cuiyu Meng
Nengwang Yu
Feilong Yang
Cong Zhang
Dawei Li
Lei Yan
Hainan Liu
Zhonghua Xu
author_sort Hui Wang
title Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors
title_short Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors
title_full Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors
title_fullStr Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors
title_full_unstemmed Serum Cystatin C Level Is Not a Promising Biomarker for Predicting Clinicopathological Characteristics of Bladder Urothelial Tumors
title_sort serum cystatin c level is not a promising biomarker for predicting clinicopathological characteristics of bladder urothelial tumors
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2018-01-01
description The role of cystatin C (Cys-C) in tumorigenesis and progression of bladder urothelial tumors (BUT) is still indefinite. We retrospectively collected the clinical information from the records of 425 BUT patients. Pretreatment serum Cys-C levels were compared across the various groups. Then we subgroup the patients with GFR ≥ 90 mg/min/1.73 m2, to exclude the effects of lower renal function on cystatin C. No statistically significant differences in the levels of serum Cys-C were found among the tumor characteristics (all P>0.05). In conclusion, circulating Cys-C was not a reliable predictor for clinicopathological characteristics of BUT patients.
url http://dx.doi.org/10.1155/2018/2617439
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