Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells

Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells

Chronic inflammation and oxidative stress (OS) are present in Alzheimer´s disease (AD) brains in addition to neuronal loss, Amyloid-β (Aβ) plaques and hyperphosphorylated tau-protein neurofibrillary tangles. Previously we showed that levels of the pro-inflammatory cytokine, interleukin-18 (IL-18), a...

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Bibliographic Details
Main Authors: Elina M Sutinen, Minna A Korolainen, Jukka eHäyrinen, Irina eAlafuzoff, Steven ePetratos, Antero eSalminen, Hilkka eSoininen, Tuula ePirttilä, Johanna O Ojala
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Inflammation
Interleukin-18
Mass Spectrometry
Proteomics
Alzheimer’s disease
14-3-3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00214/full

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