Potential Diagnostic Systems for Coronavirus Detection: a Critical Review

• Main Authors: Elena Ekrami, Mahdi Pouresmaieli, Fatemeh Barati, Sahar Asghari, Farzad Ramezani Ziarani, Parvin Shariati, Matin Mamoudifard
• Format: Article
• Language: English
• Published: BMC 2020-09-01
• Series: Biological Procedures Online
• Subjects: SARS-CoV-2; Detection; Biosensor; RT-PCR; Immunoassay; Nano-materials
• Online Access: http://link.springer.com/article/10.1186/s12575-020-00134-4

Abstract Currently there are no effective anti-viral drugs for SARS-CoV-2, so the primary line of defense is to detect infected cases as soon as possible. The high rate of contagion for this virus and the highly nonspecific symptoms of the disease (Coronovirus disease 2019, (Covid-19)) that it causes, such as respiratory symptoms, cough, dyspnea, fever, and viral pneumonia, require the urgent establishment of precise and fast diagnostic tests to verify suspected cases, screen patients, and conduct virus surveillance. Nowadays, several virus detection methods are available for viral diseases, which act on specific properties of each virus or virus family, therefore, further investigations and trials are needed to find a highly efficient and accurate detection method to detect and prevent the outcomes of the disease. Hence, there is an urgent need for more and precise studies in this field. In this review, we discussed the properties of a new generation of coronaviruses (SARS-CoV-2) following routine virus detection methods and proposed new strategies and the use of potential samples for SARS-CoV-2 detection. Graphical Abstract