Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

Metformin, the most widely used anti-diabetic drug, also exhibits anti-cancer properties; however, the true potential of metformin as an anticancer drug remains largely unknown. In this study using mouse microvascular endothelial cells (MMECs), we investigated the effects of metformin alone or in co...

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Bibliographic Details
Main Authors: Samson Mathews Samuel, Noothan Jyothi Satheesh, Suparna Ghosh, Dietrich Büsselberg, Yasser Majeed, Hong Ding, Chris R. Triggle
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
angiogenesis
cancer
combination therapy
metformin
organic cation transporter (oct)
tumor endothelial cells
Online Access:https://www.mdpi.com/2072-6694/11/11/1737

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