Direct Synthesis of Bicyclic Acetals via Visible Light Catalysis

Summary: Polysubstituted bicyclic acetals are a class of privileged pharmacophores with a unique 3D structure and an adjacent pair of hydrogen bond acceptors. The key, fused acetal functionality is often assembled, via intramolecular cyclization, from linear substrates that are not readily available...

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Bibliographic Details
Main Authors: Fengjin Wu, Leifeng Wang, Ying Ji, Ge Zou, Hong Shen, David A. Nicewicz, Jiean Chen, Yong Huang
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305836