IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection

IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection

Pulmonary infection is a leading cause of hospitalization in world. Lung damage due to infection and host mediated pathology can have life threatening consequences. Factors that limit lung injury and/or promote epithelial barrier function and repair are highly desirable as immunomodulatory therapeut...

Full description

Bibliographic Details
Main Author: John F. Alcorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
lung
interleukin
mucosa
influenza
bacteria
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01160/full
id doaj-03958d15a6884ceba28365be01e46acc
record_format Article
spelling doaj-03958d15a6884ceba28365be01e46acc2020-11-25T02:27:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-06-011110.3389/fimmu.2020.01160545002IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary InfectionJohn F. AlcornPulmonary infection is a leading cause of hospitalization in world. Lung damage due to infection and host mediated pathology can have life threatening consequences. Factors that limit lung injury and/or promote epithelial barrier function and repair are highly desirable as immunomodulatory therapeutics. Over the last decade, interleukin−22 has been shown to have pulmonary epithelial protective functions at the mucosal immune interface with bacterial and viral pathogens. This article summarizes recent findings in this area and provides perspective regarding the role of IL-22 in mucosal host defense.https://www.frontiersin.org/article/10.3389/fimmu.2020.01160/fulllunginterleukinmucosainfluenzabacteria
collection DOAJ
language English
format Article
sources DOAJ
author John F. Alcorn
spellingShingle John F. Alcorn
IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection
Frontiers in Immunology
lung
interleukin
mucosa
influenza
bacteria
author_facet John F. Alcorn
author_sort John F. Alcorn
title IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection
title_short IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection
title_full IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection
title_fullStr IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection
title_full_unstemmed IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection
title_sort il-22 plays a critical role in maintaining epithelial integrity during pulmonary infection
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2020-06-01
description Pulmonary infection is a leading cause of hospitalization in world. Lung damage due to infection and host mediated pathology can have life threatening consequences. Factors that limit lung injury and/or promote epithelial barrier function and repair are highly desirable as immunomodulatory therapeutics. Over the last decade, interleukin−22 has been shown to have pulmonary epithelial protective functions at the mucosal immune interface with bacterial and viral pathogens. This article summarizes recent findings in this area and provides perspective regarding the role of IL-22 in mucosal host defense.
topic lung
interleukin
mucosa
influenza
bacteria
url https://www.frontiersin.org/article/10.3389/fimmu.2020.01160/full
work_keys_str_mv AT johnfalcorn il22playsacriticalroleinmaintainingepithelialintegrityduringpulmonaryinfection
_version_ 1724844192564248576

Similar Items