DFR-Typing of <i>Yersinia pestis</i> Strains from the CIS Natural Foci

• Main Authors: M. E. Platonov, V. V. Evseeva, D. V. Efremenko, I. V. Kuznetsova, E. V. Chirkova, S. V. Dentovskaya, A. N. Kulichenko, A. P. Anisimov
• Format: Article
• Language: Russian
• Published: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2011-04-01
• Series: Проблемы особо опасных инфекций
• Subjects: dfr-typing; <i>yersinia pestis</i>
• Online Access: https://journal.microbe.ru/jour/article/view/746
• ISSN: 0370-1069; 2658-719X

Different region analysis (DFR-typing) was used for characterization of 275 Y. pestis strains isolated mainly from the CIS natural plague foci. Genomovars (DFR-types) endemic for 27 natural foci were determined. In addition to 32 genomovars described previously 64 novel Y. pestis DFR-types were revealed. 56 genomovars were shown to circulate in CIS and Mongolia. All strains analyzed by DFR-typing, were clustered in accordance with the phylogenetic tree proposed on the basis of combined SNP- and IS100-typing data. The discriminatory ability of the method is high enough to distinguish between subspecies, populations and even strains circulating in certain natural plague focus.