Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were...

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Main Authors: Supanna Techasakul, Supa Hannongbua, Suda Louisirirotchanakul, Pornpan Pungpo, Patchareenart Saparpakorn, Nitirat Chimnoi, Nisachon Khunnawutmanotham
Format: Article
Language:English
Published: MDPI AG 2007-02-01
Series:Molecules
Subjects:
Dipyridodiazepinone
HIV-1 RT
antiviral activity
Online Access:http://www.mdpi.com/1420-3049/12/2/218/
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spelling doaj-038fde6148c449759a751172fcf09fd22020-11-24T23:44:21ZengMDPI AGMolecules1420-30492007-02-0112221823010.3390/12020218Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse TranscriptaseSupanna TechasakulSupa HannongbuaSuda LouisirirotchanakulPornpan PungpoPatchareenart SaparpakornNitirat ChimnoiNisachon KhunnawutmanothamBased on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were found to exhibit virustatic activity comparable to some clinically usedtherapeutic agents.http://www.mdpi.com/1420-3049/12/2/218/DipyridodiazepinoneHIV-1 RTantiviral activity
collection DOAJ
language English
format Article
sources DOAJ
author Supanna Techasakul
Supa Hannongbua
Suda Louisirirotchanakul
Pornpan Pungpo
Patchareenart Saparpakorn
Nitirat Chimnoi
Nisachon Khunnawutmanotham
spellingShingle Supanna Techasakul
Supa Hannongbua
Suda Louisirirotchanakul
Pornpan Pungpo
Patchareenart Saparpakorn
Nitirat Chimnoi
Nisachon Khunnawutmanotham
Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
Molecules
Dipyridodiazepinone
HIV-1 RT
antiviral activity
author_facet Supanna Techasakul
Supa Hannongbua
Suda Louisirirotchanakul
Pornpan Pungpo
Patchareenart Saparpakorn
Nitirat Chimnoi
Nisachon Khunnawutmanotham
author_sort Supanna Techasakul
title Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
title_short Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
title_full Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
title_fullStr Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
title_full_unstemmed Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
title_sort novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against hiv-1 reverse transcriptase
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2007-02-01
description Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were found to exhibit virustatic activity comparable to some clinically usedtherapeutic agents.
topic Dipyridodiazepinone
HIV-1 RT
antiviral activity
url http://www.mdpi.com/1420-3049/12/2/218/
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AT supahannongbua novel2chloro8arylthiomethyldipyridodiazepinonederivativeswithactivityagainsthiv1reversetranscriptase
AT sudalouisirirotchanakul novel2chloro8arylthiomethyldipyridodiazepinonederivativeswithactivityagainsthiv1reversetranscriptase
AT pornpanpungpo novel2chloro8arylthiomethyldipyridodiazepinonederivativeswithactivityagainsthiv1reversetranscriptase
AT patchareenartsaparpakorn novel2chloro8arylthiomethyldipyridodiazepinonederivativeswithactivityagainsthiv1reversetranscriptase
AT nitiratchimnoi novel2chloro8arylthiomethyldipyridodiazepinonederivativeswithactivityagainsthiv1reversetranscriptase
AT nisachonkhunnawutmanotham novel2chloro8arylthiomethyldipyridodiazepinonederivativeswithactivityagainsthiv1reversetranscriptase
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