Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were...

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Bibliographic Details
Main Authors: Supanna Techasakul, Supa Hannongbua, Suda Louisirirotchanakul, Pornpan Pungpo, Patchareenart Saparpakorn, Nitirat Chimnoi, Nisachon Khunnawutmanotham
Format: Article
Language:English
Published: MDPI AG 2007-02-01
Series:Molecules
Subjects:
Dipyridodiazepinone
HIV-1 RT
antiviral activity
Online Access:http://www.mdpi.com/1420-3049/12/2/218/
Description
Summary:Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were found to exhibit virustatic activity comparable to some clinically usedtherapeutic agents.
ISSN:1420-3049

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