Omics-based biomarkers: current status and potential use in the clinic

• Main Authors: Héctor Quezada, Ana Laura Guzmán-Ortiz, Hugo Díaz-Sánchez, Ricardo Valle-Rios, Jesús Aguirre-Hernández
• Format: Article
• Language: English
• Published: Permanyer 2017-05-01
• Series: Boletín Médico del Hospital Infantil de México
• Subjects: Biomarker; Genomics; Proteomics; Metabolomics
• Online Access: http://www.sciencedirect.com/science/article/pii/S1665114617300680

In recent years, the use of high-throughput omics technologies has led to the rapid discovery of many candidate biomarkers. However, few of them have made the transition to the clinic. In this review, the promise of omics technologies to contribute to the process of biomarker development is described. An overview of the current state in this area is presented with examples of genomics, proteomics, transcriptomics, metabolomics and microbiomics biomarkers in the field of oncology, along with some proposed strategies to accelerate their validation and translation to improve the care of patients with neoplasms. The inherent complexity underlying neoplasms combined with the requirement of developing well-designed biomarker discovery processes based on omics technologies present a challenge for the effective development of biomarkers that may be useful in guiding therapies, addressing disease risks, and predicting clinical outcomes.