Somatic mutations of isocitrate dehydrogenases 1 and 2 are prognostic and follow-up markers in patients with acute myeloid leukaemia with normal karyotype

Mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes are frequent molecular lesions in acute myeloid leukaemia with normal karyotype (AML-NK). The effects of IDH mutations on clinical features and treatment outcome in AML-NK have been widely investigated, but only a few studies mo...

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Main Authors: Virijevic Marijana, Karan-Djurasevic Teodora, Marjanovic Irena, Tosic Natasa, Mitrovic Mirjana, Djunic Irena, Colovic Natasa, Vidovic Ana, Suvajdzic-Vukovic Nada, Tomin Dragica, Pavlovic Sonja
Format: Article
Language:English
Published: Sciendo 2016-12-01
Series:Radiology and Oncology
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Online Access:https://doi.org/10.1515/raon-2016-0044
Description
Summary:Mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes are frequent molecular lesions in acute myeloid leukaemia with normal karyotype (AML-NK). The effects of IDH mutations on clinical features and treatment outcome in AML-NK have been widely investigated, but only a few studies monitored these mutations during follow-up.
ISSN:1581-3207