Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

Abstract Background Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion...

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Bibliographic Details
Main Authors: Amol T. Kothekar, Jigeeshu Vasishtha Divatia, Sheila Nainan Myatra, Anand Patil, Manjunath Nookala Krishnamurthy, Harish Mallapura Maheshwarappa, Suhail Sarwar Siddiqui, Murari Gurjar, Sanjay Biswas, Vikram Gota
Format: Article
Language:English
Published: SpringerOpen 2020-01-01
Series:Annals of Intensive Care
Subjects:
Meropenem dosing
Anti-bacterial agents
Antimicrobial pharmacokinetics
Septic shock
Online Access:https://doi.org/10.1186/s13613-019-0622-8

Internet

https://doi.org/10.1186/s13613-019-0622-8

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