New Insights About Doxorubicin-Induced Toxicity to Cardiomyoblast-Derived H9C2 Cells and Dexrazoxane Cytoprotective Effect: Contribution of In Vitro1H-NMR Metabonomics

New Insights About Doxorubicin-Induced Toxicity to Cardiomyoblast-Derived H9C2 Cells and Dexrazoxane Cytoprotective Effect: Contribution of In Vitro1H-NMR Metabonomics

Doxorubicin (DOX) is an anticancer drug widely used in oncology. The main limitation to DOX treatments though is due to the cumulative dose that may lead to cardiotoxicity. Clinically, DOX-induced cardiomyopathy develops as a progressive heart failure consecutive to a progressive loss in cardiomyocy...

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Bibliographic Details
Main Authors: Matthieu Dallons, Corentin Schepkens, Aurélie Dupuis, Vanessa Tagliatti, Jean-Marie Colet
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
cardiotoxicity
dexrazoxane
H9C2
metabonomics
1H-NMR
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00079/full

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