Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus

Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus

Non-MHC linked genes may contribute to genetic predisposition to the development of systemic lupus erythematosus. The possibility that cytokine genes may be involved was raised by the observation of increased frequency in expression of an uncommon allele of an interleukin-I receptor antagonist gene...

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Main Authors: Victor A. Danis, Michelle Millington, Qirong Huang, Valentine Hyland, David Grennan
Format: Article
Language:English
Published: Hindawi Limited 1994-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/1994/464787
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spelling doaj-0368958a7c5b449991ece9f7165703cb2020-11-24T23:32:56ZengHindawi LimitedDisease Markers0278-02401875-86301994-01-0112213513910.1155/1994/464787Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus ErythematosusVictor A. Danis0Michelle Millington1Qirong Huang2Valentine Hyland3David Grennan4Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, AustraliaKolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, AustraliaDepartment of Rheumatology, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, AustraliaKolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, AustraliaDepartment of Rheumatology, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, AustraliaNon-MHC linked genes may contribute to genetic predisposition to the development of systemic lupus erythematosus. The possibility that cytokine genes may be involved was raised by the observation of increased frequency in expression of an uncommon allele of an interleukin-I receptor antagonist gene polymorphism and SLE in a recent U.K. study. We have not been able to show any significant differences in expression of this allele in SLE patients as a whole or in any patient subgroups. Our results actually show a slight decrease in the expression of this allele in SLE patients compared with healthy controls and in SLE patients with malar rash compared with SLE patients without malar rash.http://dx.doi.org/10.1155/1994/464787
collection DOAJ
language English
format Article
sources DOAJ
author Victor A. Danis
Michelle Millington
Qirong Huang
Valentine Hyland
David Grennan
spellingShingle Victor A. Danis
Michelle Millington
Qirong Huang
Valentine Hyland
David Grennan
Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus
Disease Markers
author_facet Victor A. Danis
Michelle Millington
Qirong Huang
Valentine Hyland
David Grennan
author_sort Victor A. Danis
title Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus
title_short Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus
title_full Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus
title_fullStr Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus
title_full_unstemmed Lack of Association between an Interleukin-I Receptor Antagonist Gene Polymorphism and Systemic Lupus Erythematosus
title_sort lack of association between an interleukin-i receptor antagonist gene polymorphism and systemic lupus erythematosus
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 1994-01-01
description Non-MHC linked genes may contribute to genetic predisposition to the development of systemic lupus erythematosus. The possibility that cytokine genes may be involved was raised by the observation of increased frequency in expression of an uncommon allele of an interleukin-I receptor antagonist gene polymorphism and SLE in a recent U.K. study. We have not been able to show any significant differences in expression of this allele in SLE patients as a whole or in any patient subgroups. Our results actually show a slight decrease in the expression of this allele in SLE patients compared with healthy controls and in SLE patients with malar rash compared with SLE patients without malar rash.
url http://dx.doi.org/10.1155/1994/464787
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AT michellemillington lackofassociationbetweenaninterleukinireceptorantagonistgenepolymorphismandsystemiclupuserythematosus
AT qironghuang lackofassociationbetweenaninterleukinireceptorantagonistgenepolymorphismandsystemiclupuserythematosus
AT valentinehyland lackofassociationbetweenaninterleukinireceptorantagonistgenepolymorphismandsystemiclupuserythematosus
AT davidgrennan lackofassociationbetweenaninterleukinireceptorantagonistgenepolymorphismandsystemiclupuserythematosus
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