Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy
There is a growing body of evidence that neural stem cells reside in the adult central nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone, wh...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2007-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2007/73754 |
| Summary: | There is a growing body of evidence that neural stem cells reside in the adult central
nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns
mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus
and the subventricular zone, where it is controlled by several trophic factors and neuroactive
molecules. Neurogenesis is involved in processes such as learning and memory and
accumulating evidence implicates hippocampal neurogenesis in the physiopathology of
depression. We herein review experimental and clinical data demonstrating that stress
and antidepressant treatments affect neurogenesis in opposite direction in rodents.
In particular, the stimulation of hippocampal neurogenesis by all types of antidepressant drugs
supports the view that neuroplastic phenomena are involved in the physiopathology of
depression and underlie—at least partly—antidepressant therapy. |
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| ISSN: | 2090-5904 1687-5443 |