Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia

Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease that manifests with chronic intravascular hemolysis, thrombosis, and bone marrow failure. Various degrees of cytopenias accompany the disease. Although laboratory and clinical findings are similar, the disease may show differen...

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Bibliographic Details
Main Authors: Volkan Karakuş, Egemen Kaya, Yelda Dere, Fahri Şahin
Format: Article
Language:English
Published: PAGEPress Publications 2021-09-01
Series:Italian Journal of Medicine
Subjects:
Paroxysmal nocturnal hemoglobinuria
thrombocytopenia
aplastic anemia
Online Access:https://www.italjmed.org/index.php/ijm/article/view/1319
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spelling doaj-0360e3947d9a48c7a401617918bfb90a2021-09-28T07:08:21ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522021-09-0115310.4081/itjm.2021.1319Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopeniaVolkan Karakuş0Egemen Kaya1Yelda Dere2Fahri Şahin3Department of Hematology, Alanya Alaaddin Keykubat University, School of Medicine; PNH Education and Study Group (PESG), AntalyaDepartment of Physiology Muğla Sıtkı Koçman University, School of Medicine, AntalyaDepartment of Pathology, Muğla Sıtkı Koçman University Educational and Research Hospital, AntalyaPNH Education and Study Group (PESG); Department of Hematology, Ege University, Antalya, Turkey Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease that manifests with chronic intravascular hemolysis, thrombosis, and bone marrow failure. Various degrees of cytopenias accompany the disease. Although laboratory and clinical findings are similar, the disease may show different courses and require different treatments. Herein, we report two different courses of PNH with similar clinical and laboratory findings. https://www.italjmed.org/index.php/ijm/article/view/1319Paroxysmal nocturnal hemoglobinuriathrombocytopeniaaplastic anemia
collection DOAJ
language English
format Article
sources DOAJ
author Volkan Karakuş
Egemen Kaya
Yelda Dere
Fahri Şahin
spellingShingle Volkan Karakuş
Egemen Kaya
Yelda Dere
Fahri Şahin
Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia
Italian Journal of Medicine
Paroxysmal nocturnal hemoglobinuria
thrombocytopenia
aplastic anemia
author_facet Volkan Karakuş
Egemen Kaya
Yelda Dere
Fahri Şahin
author_sort Volkan Karakuş
title Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia
title_short Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia
title_full Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia
title_fullStr Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia
title_full_unstemmed Different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia
title_sort different clinical courses with the same findings: two cases of paroxysmal nocturnal hemoglobinuria presenting with thrombocytopenia
publisher PAGEPress Publications
series Italian Journal of Medicine
issn 1877-9344
1877-9352
publishDate 2021-09-01
description Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease that manifests with chronic intravascular hemolysis, thrombosis, and bone marrow failure. Various degrees of cytopenias accompany the disease. Although laboratory and clinical findings are similar, the disease may show different courses and require different treatments. Herein, we report two different courses of PNH with similar clinical and laboratory findings.
topic Paroxysmal nocturnal hemoglobinuria
thrombocytopenia
aplastic anemia
url https://www.italjmed.org/index.php/ijm/article/view/1319
work_keys_str_mv AT volkankarakus differentclinicalcourseswiththesamefindingstwocasesofparoxysmalnocturnalhemoglobinuriapresentingwiththrombocytopenia
AT egemenkaya differentclinicalcourseswiththesamefindingstwocasesofparoxysmalnocturnalhemoglobinuriapresentingwiththrombocytopenia
AT yeldadere differentclinicalcourseswiththesamefindingstwocasesofparoxysmalnocturnalhemoglobinuriapresentingwiththrombocytopenia
AT fahrisahin differentclinicalcourseswiththesamefindingstwocasesofparoxysmalnocturnalhemoglobinuriapresentingwiththrombocytopenia
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