MTHFR - Ala222Val Effects on Metabolic Syndrome Progression

MTHFR - Ala222Val Effects on Metabolic Syndrome Progression

Objective: Methylene-tetrahydrofolate reductase (MTHFR) is involved in adapting metabolism to environmental challenges by various mechanisms, including the control of gene expression by epigenetic and post-translational changes of transcription factors. Though a metabolic syndrome candidate gene, as...

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Main Authors: Csép Katalin, Szigeti Eszter, Szalman Krisztina
Format: Article
Language:English
Published: Sciendo 2018-06-01
Series:Acta Medica Marisiensis
Subjects:
metabolic syndrome x
atherosclerosis
non-alcoholic fatty liver disease
methylenetetrahydrofolate reductase
genetic polymorphism
Online Access:https://doi.org/10.2478/amma-2018-0009
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spelling doaj-035bfc9c77484ef493918c6b392c23622021-09-06T19:41:11ZengSciendoActa Medica Marisiensis2247-61132018-06-01642646910.2478/amma-2018-0009amma-2018-0009MTHFR - Ala222Val Effects on Metabolic Syndrome ProgressionCsép Katalin0Szigeti Eszter1Szalman Krisztina2University of Medicine and Pharmacy Tirgu Mures, RomaniaUniversity of Medicine and Pharmacy Tirgu Mures, RomaniaUniversity of Medicine and Pharmacy Tirgu Mures, RomaniaObjective: Methylene-tetrahydrofolate reductase (MTHFR) is involved in adapting metabolism to environmental challenges by various mechanisms, including the control of gene expression by epigenetic and post-translational changes of transcription factors. Though a metabolic syndrome candidate gene, association studies of its common polymorphism rs1801133 (MTHFR-Ala222Val) remain inconclusive with important ethnic differences, and the effect on disease progression was not addressed.https://doi.org/10.2478/amma-2018-0009metabolic syndrome xatherosclerosisnon-alcoholic fatty liver diseasemethylenetetrahydrofolate reductasegenetic polymorphism
collection DOAJ
language English
format Article
sources DOAJ
author Csép Katalin
Szigeti Eszter
Szalman Krisztina
spellingShingle Csép Katalin
Szigeti Eszter
Szalman Krisztina
MTHFR - Ala222Val Effects on Metabolic Syndrome Progression
Acta Medica Marisiensis
metabolic syndrome x
atherosclerosis
non-alcoholic fatty liver disease
methylenetetrahydrofolate reductase
genetic polymorphism
author_facet Csép Katalin
Szigeti Eszter
Szalman Krisztina
author_sort Csép Katalin
title MTHFR - Ala222Val Effects on Metabolic Syndrome Progression
title_short MTHFR - Ala222Val Effects on Metabolic Syndrome Progression
title_full MTHFR - Ala222Val Effects on Metabolic Syndrome Progression
title_fullStr MTHFR - Ala222Val Effects on Metabolic Syndrome Progression
title_full_unstemmed MTHFR - Ala222Val Effects on Metabolic Syndrome Progression
title_sort mthfr - ala222val effects on metabolic syndrome progression
publisher Sciendo
series Acta Medica Marisiensis
issn 2247-6113
publishDate 2018-06-01
description Objective: Methylene-tetrahydrofolate reductase (MTHFR) is involved in adapting metabolism to environmental challenges by various mechanisms, including the control of gene expression by epigenetic and post-translational changes of transcription factors. Though a metabolic syndrome candidate gene, association studies of its common polymorphism rs1801133 (MTHFR-Ala222Val) remain inconclusive with important ethnic differences, and the effect on disease progression was not addressed.
topic metabolic syndrome x
atherosclerosis
non-alcoholic fatty liver disease
methylenetetrahydrofolate reductase
genetic polymorphism
url https://doi.org/10.2478/amma-2018-0009
work_keys_str_mv AT csepkatalin mthfrala222valeffectsonmetabolicsyndromeprogression
AT szigetieszter mthfrala222valeffectsonmetabolicsyndromeprogression
AT szalmankrisztina mthfrala222valeffectsonmetabolicsyndromeprogression
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