Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer

Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer

Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. PLK4 is overexpressed in BC cell lines and tissue...

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Bibliographic Details
Main Authors: Ziyi Yang, Haiyan Sun, Wenlong Ma, Kai Wu, Guoyu Peng, Tong Ou, Song Wu
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:FEBS Open Bio
Subjects:
bladder cancer
G1 phase arrest
p38/p53/p21 pathway
polo‐like kinase 4
Online Access:https://doi.org/10.1002/2211-5463.13262

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