Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer

Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer

Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. PLK4 is overexpressed in BC cell lines and tissue...

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Main Authors: Ziyi Yang, Haiyan Sun, Wenlong Ma, Kai Wu, Guoyu Peng, Tong Ou, Song Wu
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:FEBS Open Bio
Subjects:
bladder cancer
G1 phase arrest
p38/p53/p21 pathway
polo‐like kinase 4
Online Access:https://doi.org/10.1002/2211-5463.13262
id doaj-0353550ac85c401e8cc2633be5e29a87
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spelling doaj-0353550ac85c401e8cc2633be5e29a872021-09-01T13:38:20ZengWileyFEBS Open Bio2211-54632021-09-011192631264610.1002/2211-5463.13262Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancerZiyi Yang0Haiyan Sun1Wenlong Ma2Kai Wu3Guoyu Peng4Tong Ou5Song Wu6Shenzhen University Health Science Center ChinaInstitute of Urology The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group) ChinaInstitute of Urology The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group) ChinaInstitute of Urology The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group) ChinaInstitute of Urology The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group) ChinaInstitute of Urology The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group) ChinaShenzhen University Health Science Center ChinaPolo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. PLK4 is overexpressed in BC cell lines and tissues, and its overexpression correlated with poor prognosis. Our transcriptome analysis combined with subsequent functional assays indicated that PLK4 inhibition can suppress BC cell growth and induce cell cycle arrest at G1 phase via activation of the p38/p53/p21 pathway in vitro and in vivo. Overall, our data suggest that PLK4 is a critical regulator of BC cell proliferation, and thus, it may have potential as a novel molecular target for BC treatment.https://doi.org/10.1002/2211-5463.13262bladder cancerG1 phase arrestp38/p53/p21 pathwaypolo‐like kinase 4
collection DOAJ
language English
format Article
sources DOAJ
author Ziyi Yang
Haiyan Sun
Wenlong Ma
Kai Wu
Guoyu Peng
Tong Ou
Song Wu
spellingShingle Ziyi Yang
Haiyan Sun
Wenlong Ma
Kai Wu
Guoyu Peng
Tong Ou
Song Wu
Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
FEBS Open Bio
bladder cancer
G1 phase arrest
p38/p53/p21 pathway
polo‐like kinase 4
author_facet Ziyi Yang
Haiyan Sun
Wenlong Ma
Kai Wu
Guoyu Peng
Tong Ou
Song Wu
author_sort Ziyi Yang
title Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_short Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_full Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_fullStr Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_full_unstemmed Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_sort down‐regulation of polo‐like kinase 4 (plk4) induces g1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
publisher Wiley
series FEBS Open Bio
issn 2211-5463
publishDate 2021-09-01
description Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. PLK4 is overexpressed in BC cell lines and tissues, and its overexpression correlated with poor prognosis. Our transcriptome analysis combined with subsequent functional assays indicated that PLK4 inhibition can suppress BC cell growth and induce cell cycle arrest at G1 phase via activation of the p38/p53/p21 pathway in vitro and in vivo. Overall, our data suggest that PLK4 is a critical regulator of BC cell proliferation, and thus, it may have potential as a novel molecular target for BC treatment.
topic bladder cancer
G1 phase arrest
p38/p53/p21 pathway
polo‐like kinase 4
url https://doi.org/10.1002/2211-5463.13262
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