Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.
AID (Activation Induced Deaminase) deaminates cytosines in DNA to initiate immunoglobulin gene diversification and to reprogram CpG methylation in early development. AID is potentially highly mutagenic, and it causes genomic instability evident as translocations in B cell malignancies. Here we show...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-09-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4565580?pdf=render |