Balancing immune protection and immune pathology by CD8+ T cell responses to influenza infection

Balancing immune protection and immune pathology by CD8+ T cell responses to influenza infection

Influenza A virus (IAV) is a significant human pathogen causing annual epidemics and periodic pandemics. CD8+ cytotoxic T lymphocyte (CTL)-mediated immunity contributes to clearance of virus-infected cells; CTL immunity targeting the conserved internal proteins of IAVs is a key protection mechanism...

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Bibliographic Details
Main Authors: Susu eDuan, Paul G Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Immunology
Subjects:
Influenza, Human
Vaccination
CD8+ T cells
Immune Regulation
immunopathology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00025/full

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