Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework
Classical epidemiological approaches have been limited in their ability to formally test hypotheses. Here, Dellicour et al. illustrate how phylodynamic and phylogeographic analyses can be leveraged for hypothesis testing in molecular epidemiology using West Nile virus in North America as an example.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19122-z |
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doaj-034b011214474575a5f47f436fad92f52021-05-11T08:01:19ZengNature Publishing GroupNature Communications2041-17232020-11-0111111110.1038/s41467-020-19122-zEpidemiological hypothesis testing using a phylogeographic and phylodynamic frameworkSimon Dellicour0Sebastian Lequime1Bram Vrancken2Mandev S. Gill3Paul Bastide4Karthik Gangavarapu5Nathaniel L. Matteson6Yi Tan7Louis du Plessis8Alexander A. Fisher9Martha I. Nelson10Marius Gilbert11Marc A. Suchard12Kristian G. Andersen13Nathan D. Grubaugh14Oliver G. Pybus15Philippe Lemey16Spatial Epidemiology Lab (SpELL), Université Libre de BruxellesDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU LeuvenDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU LeuvenDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU LeuvenDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU LeuvenDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Zoology, University of OxfordDepartment of Biomathematics, David Geffen School of Medicine, University of CaliforniaFogarty International Center, National Institutes of HealthSpatial Epidemiology Lab (SpELL), Université Libre de BruxellesDepartment of Biomathematics, David Geffen School of Medicine, University of CaliforniaDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Epidemiology of Microbial Diseases, Yale School of Public HealthDepartment of Zoology, University of OxfordDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU LeuvenClassical epidemiological approaches have been limited in their ability to formally test hypotheses. Here, Dellicour et al. illustrate how phylodynamic and phylogeographic analyses can be leveraged for hypothesis testing in molecular epidemiology using West Nile virus in North America as an example.https://doi.org/10.1038/s41467-020-19122-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Simon Dellicour Sebastian Lequime Bram Vrancken Mandev S. Gill Paul Bastide Karthik Gangavarapu Nathaniel L. Matteson Yi Tan Louis du Plessis Alexander A. Fisher Martha I. Nelson Marius Gilbert Marc A. Suchard Kristian G. Andersen Nathan D. Grubaugh Oliver G. Pybus Philippe Lemey |
| spellingShingle |
Simon Dellicour Sebastian Lequime Bram Vrancken Mandev S. Gill Paul Bastide Karthik Gangavarapu Nathaniel L. Matteson Yi Tan Louis du Plessis Alexander A. Fisher Martha I. Nelson Marius Gilbert Marc A. Suchard Kristian G. Andersen Nathan D. Grubaugh Oliver G. Pybus Philippe Lemey Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework Nature Communications |
| author_facet |
Simon Dellicour Sebastian Lequime Bram Vrancken Mandev S. Gill Paul Bastide Karthik Gangavarapu Nathaniel L. Matteson Yi Tan Louis du Plessis Alexander A. Fisher Martha I. Nelson Marius Gilbert Marc A. Suchard Kristian G. Andersen Nathan D. Grubaugh Oliver G. Pybus Philippe Lemey |
| author_sort |
Simon Dellicour |
| title |
Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework |
| title_short |
Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework |
| title_full |
Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework |
| title_fullStr |
Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework |
| title_full_unstemmed |
Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework |
| title_sort |
epidemiological hypothesis testing using a phylogeographic and phylodynamic framework |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
Classical epidemiological approaches have been limited in their ability to formally test hypotheses. Here, Dellicour et al. illustrate how phylodynamic and phylogeographic analyses can be leveraged for hypothesis testing in molecular epidemiology using West Nile virus in North America as an example. |
| url |
https://doi.org/10.1038/s41467-020-19122-z |
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