Embelin Promotes Oncolytic Vaccinia Virus-Mediated Antitumor Immunity Through Disruption of IL-6/STAT3 Signaling in Lymphoma

Embelin Promotes Oncolytic Vaccinia Virus-Mediated Antitumor Immunity Through Disruption of IL-6/STAT3 Signaling in Lymphoma

Peng Wang,1 Yi Wu,2 Chen Yang,3 Guanan Zhao,4 Yonghua Liu,5 Gang Cheng,6 Shibing Wang7,8 1Medical Laboratory Center, Lishui City People’s Hospital, Lishui, People’s Republic of China; 2Department of Hematology, Zhejiang Provincial People’s Hospital, People’s H...

Full description

Bibliographic Details
Main Authors:	Wang P, Wu Y, Yang C, Zhao G, Liu Y, Cheng G, Wang S
Format:	Article
Language:	English
Published:	Dove Medical Press 2020-02-01
Series:	OncoTargets and Therapy
Subjects:	oncolytic vaccinia virus embelin il-6/stat3 immunotherapy lymphoma
Online Access:	https://www.dovepress.com/embelin-promotes-oncolytic-vaccinia-virus-mediated-antitumor-immunity--peer-reviewed-article-OTT

Similar Items

An Oncolytic Vaccinia Virus Armed with GM-CSF and IL-24 Double Genes for Cancer Targeted Therapy
by: Deng L, et al.
Published: (2020-04-01)

Bio-Engineering Vaccinia Viruses for Increased Oncolytic Potential
by: Pelin, Adrian
Published: (2019)

Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monoclonal antibody against T-cell immunoglobulin and ITIM domain (TIGIT)
by: Shuguang Zuo, et al.
Published: (2021-02-01)

Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE)
by: M. Moehler, et al.
Published: (2019-08-01)

Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus
by: Jing Ma, et al.
Published: (2021-06-01)

Enhancing the Oncolytic Efficacy of Vaccinia Virus by Mutagenic Augmentation of EEV Production
by: Laporte, Aimée N.
Published: (2012)

Enhancing the Oncolytic Efficacy of Vaccinia Virus by Mutagenic Augmentation of EEV Production
by: Laporte, Aimée N.
Published: (2012)

High Oncolytic Activity of a Double-Deleted Vaccinia Virus Copenhagen Strain against Malignant Pleural Mesothelioma
by: Tiphaine Delaunay, et al.
Published: (2020-09-01)

Embelin impairs the accumulation and activation of MDSCs in colitis-associated tumorigenesis
by: Ting Wu, et al.
Published: (2018-11-01)

First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells
by: Boris R. Minev, et al.
Published: (2019-08-01)

Tachypleus tridentatus Lectin Enhances Oncolytic Vaccinia Virus Replication to Suppress In Vivo Hepatocellular Carcinoma Growth
by: Gongchu Li, et al.
Published: (2018-06-01)

Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
by: Samantha Turnbull, et al.
Published: (2015-12-01)

Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus
by: Zong Sheng Guo, et al.
Published: (2017-12-01)

Fluorescent Tagged Vaccinia Virus Genome Allows Rapid and Efficient Measurement of Oncolytic Potential and Discovery of Oncolytic Modulators
by: Franck Gallardo, et al.
Published: (2020-11-01)

The JAK/STAT3 signaling pathway in vaccinia virus infection
by: Zhou, Yanan
Published: (2018)

Oncolytic Vaccinia Virus Expressing <i>Aphrocallistes vastus</i> Lectin as a Cancer Therapeutic Agent
by: Tao Wu, et al.
Published: (2019-06-01)

Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers
by: Dobrin D. Draganov, et al.
Published: (2019-03-01)

The Application of Embelin for Cancer Prevention and Therapy
by: Jeong-Hyeon Ko, et al.
Published: (2018-03-01)

Synergistic suppression effect on tumor growth of acute myeloid leukemia by combining cytarabine with an engineered oncolytic vaccinia virus
by: Peng J, et al.
Published: (2018-10-01)

Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes
by: Heinrich B, et al.
Published: (2017-05-01)

Arming viruses in multi-mechanistic oncolytic viral therapy: current research and future developments, with emphasis on poxviruses
by: Sampath P, et al.
Published: (2013-12-01)

Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus
by: Claudia Hill, et al.
Published: (2021-06-01)

Haliotis discus discus Sialic Acid-Binding Lectin Reduces the Oncolytic Vaccinia Virus Induced Toxicity in a Glioblastoma Mouse Model
by: Gongchu Li, et al.
Published: (2018-04-01)

Antioxidant and inhibition of senescence effects of embelin
by: Jin Jung Ahn, et al.
Published: (2018-03-01)

Safety studies and viral shedding of intramuscular administration of oncolytic vaccinia virus TG6002 in healthy beagle dogs
by: Jérémy Béguin, et al.
Published: (2020-08-01)

Characterization of the Role of Necroptosis for Oncolytic Vaccinia Efficacy
Published: (2020)

Oncolytic vaccinia virus GLV-1h68 exhibits profound antitumoral activities in cell lines originating from neuroendocrine neoplasms
by: Linus D. Kloker, et al.
Published: (2020-07-01)

Oncolytic vaccinia virus induces a novel phenotype of CD8+ effector T cells characterized by high ICOS expression
by: Midori Yamashita, et al.
Published: (2021-03-01)

Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens
by: Nian-Zhi Ning, et al.
Published: (2018-01-01)

Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL-24 gene in liver cancer cells
by: Fang, H., et al.
Published: (2021)

In Vitro Analysis of the Antioxidant and Antiviral Activity of Embelin Against Herpes Simplex Virus-1
by: Tony Elias, et al.
Published: (2021-02-01)

Enhancing therapeutic efficacy of oncolytic vaccinia virus armed with Beclin-1, an autophagic Gene in leukemia and myeloma
by: Wen Lei, et al.
Published: (2020-05-01)

Oncolytic Vaccinia Virus Expressing White-Spotted Charr Lectin Regulates Antiviral Response in Tumor Cells and Inhibits Tumor Growth In Vitro and In Vivo
by: Xue Wang, et al.
Published: (2021-05-01)

Overcoming Tumor Resistance to Oncolyticvaccinia Virus with Anti-PD-1-Based Combination Therapy by Inducing Antitumor Immunity in the Tumor Microenvironment
by: So Young Yoo, et al.
Published: (2020-06-01)

Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase
by: S. M. Bakhtiar Ul Islam, et al.
Published: (2020-01-01)

Embelin can protect mice from thioacetamide-induced acute liver injury
by: Huafeng Wang, et al.
Published: (2019-10-01)

Oncolytic vaccinia virus GLV-1h68 strain shows enhanced replication in human breast cancer stem-like cells in comparison to breast cancer cells
by: Wang Huiqiang, et al.
Published: (2012-08-01)

Design and Engineering of Deimmunized Vaccinia Viral Vectors
by: Kevin Song, et al.
Published: (2020-11-01)

A model of the artificial metastasis of human epidermoid carcinoma A431 in nude mice for examination of the oncolytic activity of vaccinia virus
by: G. V. Kochneva, et al.
Published: (2015-12-01)

Preclinical Evaluation of the Oncolytic Vaccinia Virus TG6002 by Translational Research on Canine Breast Cancer
by: Jérémy Béguin, et al.
Published: (2020-12-01)