High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study

High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study

Abstract Background Although both rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (anti-CCP) are useful for diagnosing rheumatoid arthritis (RA), the impact of these autoantibodies on the efficacy of tumor necrosis factor (TNF) inhibitors has been controversial. The aim of thi...

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Bibliographic Details
Main Authors: Tsutomu Takeuchi, Nobuyuki Miyasaka, Takashi Inui, Toshiro Yano, Toru Yoshinari, Tohru Abe, Takao Koike
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Infliximab
Anticyclic citrullinated peptide antibodies
Rheumatoid factor
Clinical response
Pharmacokinetics
Online Access:http://link.springer.com/article/10.1186/s13075-017-1401-2

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http://link.springer.com/article/10.1186/s13075-017-1401-2

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