Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case report

Steven-Johnson syndrome (SJS) is a rare medical emergency that is characterized by widespread skin and mucosal lesions. Oral mucosal involvement is seen in 90% of SJS and it is often widespread and confluent. In the majority of the cases, the symptoms are associated with an adverse drug reaction, us...

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Main Authors: Aderonke Omolola Oluwo, Folakemi Olutoyin Irewole-Ojo, Cecilia Abimbola Mabogunje
Format: Article
Language:English
Published: PAMJ 2020-11-01
Series:PAMJ Clinical Medicine
Subjects:
Online Access: https://www.clinical-medicine.panafrican-med-journal.com/content/article/4/92/pdf/92.pdf
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spelling doaj-03208da712da4a51a301d1af073e284d2020-12-23T10:15:59ZengPAMJPAMJ Clinical Medicine 2707-27972707-27972020-11-0149210.11604/pamj-cm.2020.4.92.2636726367Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case reportAderonke Omolola Oluwo0Folakemi Olutoyin Irewole-Ojo1Cecilia Abimbola Mabogunje2 Dental Department, Massey Street Children Hospital, Lagos, Nigeria Medical Department, Massey Street Children Hospital, Lagos, Nigeria Medical Department, Massey Street Children Hospital, Lagos, Nigeria Steven-Johnson syndrome (SJS) is a rare medical emergency that is characterized by widespread skin and mucosal lesions. Oral mucosal involvement is seen in 90% of SJS and it is often widespread and confluent. In the majority of the cases, the symptoms are associated with an adverse drug reaction, usually to non-steroidal anti-inflammatory drugs, sulfonamides, anti-epileptics, or antibiotics. Recently, SJS associated with herbal medicine has been reported. This paper aims to report 3 cases of SJS with marked oral manifestations, following the use of local herbal medicine, diagnosed in a children´s hospital in Nigeria within a year. Three children aged 1.5, 9 and 10 years presented in our emergency unit with features of SJS, history of the use of local herbal medicine to cure an ailment was elicited in all cases before admission into our hospital. All the cases presented with cutaneous exfoliating exanthema and bullous eruptions with oral mucosa appearing as painful crusted erythematous lesions. One of the 3 cases, a male patient, presented clinically with septicaemia complicated with anaemia as well as nasal involvement. Discontinuation of herbal medicine in all cases resulted in a relief of symptoms. A multidisciplinary approach of management was instituted with resultant total recovery of patients. This case report addresses the fact that severe hypersensitivity reactions can occur with the use of herbal medicine. Emphasis should be on active vigilance in the use of herbal medicine. https://www.clinical-medicine.panafrican-med-journal.com/content/article/4/92/pdf/92.pdf herbal medicineoral lesionssteven johnson syndromechildren
collection DOAJ
language English
format Article
sources DOAJ
author Aderonke Omolola Oluwo
Folakemi Olutoyin Irewole-Ojo
Cecilia Abimbola Mabogunje
spellingShingle Aderonke Omolola Oluwo
Folakemi Olutoyin Irewole-Ojo
Cecilia Abimbola Mabogunje
Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case report
PAMJ Clinical Medicine
herbal medicine
oral lesions
steven johnson syndrome
children
author_facet Aderonke Omolola Oluwo
Folakemi Olutoyin Irewole-Ojo
Cecilia Abimbola Mabogunje
author_sort Aderonke Omolola Oluwo
title Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case report
title_short Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case report
title_full Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case report
title_fullStr Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case report
title_full_unstemmed Oral manifestations of herbal medicine induced Steven Johnson syndrome in 3 Nigerian paediatric patients: case report
title_sort oral manifestations of herbal medicine induced steven johnson syndrome in 3 nigerian paediatric patients: case report
publisher PAMJ
series PAMJ Clinical Medicine
issn 2707-2797
2707-2797
publishDate 2020-11-01
description Steven-Johnson syndrome (SJS) is a rare medical emergency that is characterized by widespread skin and mucosal lesions. Oral mucosal involvement is seen in 90% of SJS and it is often widespread and confluent. In the majority of the cases, the symptoms are associated with an adverse drug reaction, usually to non-steroidal anti-inflammatory drugs, sulfonamides, anti-epileptics, or antibiotics. Recently, SJS associated with herbal medicine has been reported. This paper aims to report 3 cases of SJS with marked oral manifestations, following the use of local herbal medicine, diagnosed in a children´s hospital in Nigeria within a year. Three children aged 1.5, 9 and 10 years presented in our emergency unit with features of SJS, history of the use of local herbal medicine to cure an ailment was elicited in all cases before admission into our hospital. All the cases presented with cutaneous exfoliating exanthema and bullous eruptions with oral mucosa appearing as painful crusted erythematous lesions. One of the 3 cases, a male patient, presented clinically with septicaemia complicated with anaemia as well as nasal involvement. Discontinuation of herbal medicine in all cases resulted in a relief of symptoms. A multidisciplinary approach of management was instituted with resultant total recovery of patients. This case report addresses the fact that severe hypersensitivity reactions can occur with the use of herbal medicine. Emphasis should be on active vigilance in the use of herbal medicine.
topic herbal medicine
oral lesions
steven johnson syndrome
children
url https://www.clinical-medicine.panafrican-med-journal.com/content/article/4/92/pdf/92.pdf
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AT ceciliaabimbolamabogunje oralmanifestationsofherbalmedicineinducedstevenjohnsonsyndromein3nigerianpaediatricpatientscasereport
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