Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway

Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway

The mRNA expression of CAPN2 was upregulated in CRPC cells (DU145 and PC3) than that in non-CRPC cells. Silencing CAPN2 expression could inhibit DU145 and PC3 cells proliferation by cell cycle arrest at G1 phase. Knockdown of CPAN2 level suppressed the migration and invasion capacity of CRPC cells b...

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Bibliographic Details
Main Authors:	Pu Li, Chenkui Miao, Chao Liang, Pengfei Shao, Zengjun Wang, Jie Li
Format:	Article
Language:	English
Published:	Hindawi Limited 2017-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2017/2593674

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