TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles

TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles

Extracellular vesicles (EV) can modulate the responses of cells to toll-like receptor (TLR) ligation; conversely, TLR ligands such as double-stranded RNA (dsRNA) can enhance the release of EV and influence of the composition and functions of EV cargos. Inflamed synovial joints in rheumatoid arthriti...

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Bibliographic Details
Main Authors: Mojca Frank-Bertoncelj, David S. Pisetsky, Christoph Kolling, Beat A. Michel, Renate E. Gay, Astrid Jüngel, Steffen Gay
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
double-stranded RNA
extracellular vesicles
Poly(I:C)
synovial fibroblasts
inflammation
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00028/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00028/full

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