Effect of Monophosphoryl Lipid A on Lipopolysaccharide-Induced Nitric Oxide Production from Raw 264.7 Macrophages
The lipid A moiety of LPS is responsible for the toxic effects of LPS. The identification of structural analogs and precursors of lipid A have demonstrated that they are apparently competitive antagonists against the biological actions of LPS. In this study we investigated the effect of Salmonella M...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bilimsel Tip Yayinevi
1997-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1997-2-2-120-126.pdf |
| Summary: | The lipid A moiety of LPS is responsible for the toxic effects of LPS. The identification of structural analogs and precursors of lipid A have demonstrated that they are apparently competitive antagonists against the biological actions of LPS. In this study we investigated the effect of Salmonella Minnesota monophosphoryl lipid A on nitric oxide (NO) secretion from Salmonella minnesota LPS-stimulated RAW 264.7 macrophages. Although monophosphoryl lipid A itself induced NO production from macrophages in a dose dependent manner, at a given concentration, monophosphoryl lipid A demonstrated inhibitory action on LPS-induced NO production from macrophages. At the concentrations equal to and lower than 0.125 µg/mL, NO inducing capacity of monophosphoryl lipid A significantly decreased along with reducing the LPS-induced NO production from RAW264.7 macrophages. |
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| ISSN: | 1300-932X 1300-932X |