Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy

Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy

The impact of a mixed neutron-gamma beam on the activation of DNA damage response (DDR) proteins and non-coding RNAs (ncRNAs) is poorly understood. Ionizing radiation is characterized by its biological effectiveness and is related to linear energy transfer (LET). Neutron-gamma mixed beam used in bor...

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Bibliographic Details
Main Authors: Kamila Maliszewska-Olejniczak, Damian Kaniowski, Martyna Araszkiewicz, Katarzyna Tymińska, Agnieszka Korgul
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
neutron mixed-beam
BNCT (boron neutron capture therapy)
DNA damage
DNA repair
high-LET
low-LET radiation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.676575/full

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