A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding “a cure.” The mere idea that cure of HIV might be possible...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Case Western Reserve University
2016-08-01
|
| Series: | Pathogens and Immunity |
| Subjects: | |
| Online Access: | https://paijournal.com/index.php/paijournal/article/view/133 |
| id |
doaj-02ebcfc2f3ba4be08d9a42eeedb59539 |
|---|---|
| record_format |
Article |
| spelling |
doaj-02ebcfc2f3ba4be08d9a42eeedb595392020-11-25T01:05:37ZengCase Western Reserve UniversityPathogens and Immunity2469-29642016-08-011115416410.20411/pai.v1i1.13323A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?Michael M. Lederman0Paula M. Cannon1Judith S. Currier2Carl H. June3Hans-Peter Kiem4Daniel R. Kuritzkes5Sharon R. Lewin6David M. Margolis7Joseph M. McCune8John W. Mellors9Timothy W. Schacker10Rafick P. Sekaly11Pablo Tebas12Bruce D. Walker13Daniel C. Douek14Case Western Reserve University School of Medicine, Cleveland, OHUniversity of Southern California, Los Angeles, CAUniversity of California, Los Angeles, Los Angeles, CAUniversity of Pennsylvania, Philadelphia, PAFred Hutchinson Cancer Research Center, Seattle, WAHarvard University, Boston, MAThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, AustraliaUniversity of North Carolina at Chapel Hill, Chapel Hill, NCUniversity of California, San Francisco, San Francisco, CAUniversity of Pittsburgh, Pittsburgh, PAUniversity of Minnesota, Minneapolis, MNCase Western Reserve University School of Medicine, Cleveland, OHUniversity of Pennsylvania, Philadelphia, PAHarvard University and Massachusetts Institute of Technology, Cambridge, MAVaccine Research Center, National Institutes of Health, Bethesda, MDWith the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding “a cure.” The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust. In this “salon” two editors of Pathogens and Immunity, Michael Lederman and Daniel Douek ask whether curing HIV is a realistic, scalable objective. We start with an overview perspective and have asked a number of prominent HIV researchers to add to the discussion.https://paijournal.com/index.php/paijournal/article/view/133HIVreservoireradicationcureCCR5functional curelatencyelite controllerBerlin Patientinflammationprocoagulant |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michael M. Lederman Paula M. Cannon Judith S. Currier Carl H. June Hans-Peter Kiem Daniel R. Kuritzkes Sharon R. Lewin David M. Margolis Joseph M. McCune John W. Mellors Timothy W. Schacker Rafick P. Sekaly Pablo Tebas Bruce D. Walker Daniel C. Douek |
| spellingShingle |
Michael M. Lederman Paula M. Cannon Judith S. Currier Carl H. June Hans-Peter Kiem Daniel R. Kuritzkes Sharon R. Lewin David M. Margolis Joseph M. McCune John W. Mellors Timothy W. Schacker Rafick P. Sekaly Pablo Tebas Bruce D. Walker Daniel C. Douek A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? Pathogens and Immunity HIV reservoir eradication cure CCR5 functional cure latency elite controller Berlin Patient inflammation procoagulant |
| author_facet |
Michael M. Lederman Paula M. Cannon Judith S. Currier Carl H. June Hans-Peter Kiem Daniel R. Kuritzkes Sharon R. Lewin David M. Margolis Joseph M. McCune John W. Mellors Timothy W. Schacker Rafick P. Sekaly Pablo Tebas Bruce D. Walker Daniel C. Douek |
| author_sort |
Michael M. Lederman |
| title |
A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? |
| title_short |
A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? |
| title_full |
A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? |
| title_fullStr |
A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? |
| title_full_unstemmed |
A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? |
| title_sort |
cure for hiv infection: “not in my lifetime” or “just around the corner”? |
| publisher |
Case Western Reserve University |
| series |
Pathogens and Immunity |
| issn |
2469-2964 |
| publishDate |
2016-08-01 |
| description |
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding “a cure.” The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust.
In this “salon” two editors of Pathogens and Immunity, Michael Lederman and Daniel Douek ask whether curing HIV is a realistic, scalable objective. We start with an overview perspective and have asked a number of prominent HIV researchers to add to the discussion. |
| topic |
HIV reservoir eradication cure CCR5 functional cure latency elite controller Berlin Patient inflammation procoagulant |
| url |
https://paijournal.com/index.php/paijournal/article/view/133 |
| work_keys_str_mv |
AT michaelmlederman acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT paulamcannon acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT judithscurrier acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT carlhjune acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT hanspeterkiem acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT danielrkuritzkes acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT sharonrlewin acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT davidmmargolis acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT josephmmccune acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT johnwmellors acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT timothywschacker acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT rafickpsekaly acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT pablotebas acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT brucedwalker acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT danielcdouek acureforhivinfectionnotinmylifetimeorjustaroundthecorner AT michaelmlederman cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT paulamcannon cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT judithscurrier cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT carlhjune cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT hanspeterkiem cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT danielrkuritzkes cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT sharonrlewin cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT davidmmargolis cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT josephmmccune cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT johnwmellors cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT timothywschacker cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT rafickpsekaly cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT pablotebas cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT brucedwalker cureforhivinfectionnotinmylifetimeorjustaroundthecorner AT danielcdouek cureforhivinfectionnotinmylifetimeorjustaroundthecorner |
| _version_ |
1725193511303643136 |