MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION

In oncology practice, despite significant advances in early cancer detection, surgery, radiotherapy, laser therapy, targeted therapy, etc., chemotherapy is unlikely to lose its relevance in the near future. In this context, the development of new antitumor agents is one of the most important problem...

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Main Authors: A. V. Zaborovskiy, K. G. Gurevich
Format: Article
Language:Russian
Published: Tomsk National Research Medical Center of the Russian Academy of Sciences 2017-06-01
Series:Sibirskij Onkologičeskij Žurnal
Subjects:
Online Access:https://www.siboncoj.ru/jour/article/view/517
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spelling doaj-02c850b0b5b14cc6abc516a1e82930342021-07-28T21:02:03ZrusTomsk National Research Medical Center of the Russian Academy of SciencesSibirskij Onkologičeskij Žurnal1814-48612312-31682017-06-01162364110.21294/1814-4861-2017-16-2-36-41432MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATIONA. V. Zaborovskiy0K. G. Gurevich1Moscow State University of Medicine and Dentistry named after A.I. EvdokimovMoscow State University of Medicine and Dentistry named after A.I. EvdokimovIn oncology practice, despite significant advances in early cancer detection, surgery, radiotherapy, laser therapy, targeted therapy, etc., chemotherapy is unlikely to lose its relevance in the near future. In this context, the development of new antitumor agents is one of the most important problems of cancer research. In spite of the importance of searching for new compounds with antitumor activity, the possibilities of the “old” agents have not been fully exhausted. Targeted delivery of antitumor agents can give them a “second life”. When developing new targeted drugs and their further introduction into clinical practice, the change in their pharmacodynamics and pharmacokinetics plays a special role. The paper describes a pharmacokinetic model of the targeted drug delivery. The conditions under which it is meaningful to search for a delivery vehicle for the active substance were described. Primary screening of antitumor agents was undertaken to modify them for the targeted delivery based on underlying assumptions of the model.https://www.siboncoj.ru/jour/article/view/517drugs directed transporttarget tissueantitumor drugs
collection DOAJ
language Russian
format Article
sources DOAJ
author A. V. Zaborovskiy
K. G. Gurevich
spellingShingle A. V. Zaborovskiy
K. G. Gurevich
MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
Sibirskij Onkologičeskij Žurnal
drugs directed transport
target tissue
antitumor drugs
author_facet A. V. Zaborovskiy
K. G. Gurevich
author_sort A. V. Zaborovskiy
title MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
title_short MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
title_full MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
title_fullStr MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
title_full_unstemmed MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
title_sort modeling of targeted drug delivery part ii. multiple drug administration
publisher Tomsk National Research Medical Center of the Russian Academy of Sciences
series Sibirskij Onkologičeskij Žurnal
issn 1814-4861
2312-3168
publishDate 2017-06-01
description In oncology practice, despite significant advances in early cancer detection, surgery, radiotherapy, laser therapy, targeted therapy, etc., chemotherapy is unlikely to lose its relevance in the near future. In this context, the development of new antitumor agents is one of the most important problems of cancer research. In spite of the importance of searching for new compounds with antitumor activity, the possibilities of the “old” agents have not been fully exhausted. Targeted delivery of antitumor agents can give them a “second life”. When developing new targeted drugs and their further introduction into clinical practice, the change in their pharmacodynamics and pharmacokinetics plays a special role. The paper describes a pharmacokinetic model of the targeted drug delivery. The conditions under which it is meaningful to search for a delivery vehicle for the active substance were described. Primary screening of antitumor agents was undertaken to modify them for the targeted delivery based on underlying assumptions of the model.
topic drugs directed transport
target tissue
antitumor drugs
url https://www.siboncoj.ru/jour/article/view/517
work_keys_str_mv AT avzaborovskiy modelingoftargeteddrugdeliverypartiimultipledrugadministration
AT kggurevich modelingoftargeteddrugdeliverypartiimultipledrugadministration
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