MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
In oncology practice, despite significant advances in early cancer detection, surgery, radiotherapy, laser therapy, targeted therapy, etc., chemotherapy is unlikely to lose its relevance in the near future. In this context, the development of new antitumor agents is one of the most important problem...
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Tomsk National Research Medical Center of the Russian Academy of Sciences
2017-06-01
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Online Access: | https://www.siboncoj.ru/jour/article/view/517 |
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doaj-02c850b0b5b14cc6abc516a1e82930342021-07-28T21:02:03ZrusTomsk National Research Medical Center of the Russian Academy of SciencesSibirskij Onkologičeskij Žurnal1814-48612312-31682017-06-01162364110.21294/1814-4861-2017-16-2-36-41432MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATIONA. V. Zaborovskiy0K. G. Gurevich1Moscow State University of Medicine and Dentistry named after A.I. EvdokimovMoscow State University of Medicine and Dentistry named after A.I. EvdokimovIn oncology practice, despite significant advances in early cancer detection, surgery, radiotherapy, laser therapy, targeted therapy, etc., chemotherapy is unlikely to lose its relevance in the near future. In this context, the development of new antitumor agents is one of the most important problems of cancer research. In spite of the importance of searching for new compounds with antitumor activity, the possibilities of the “old” agents have not been fully exhausted. Targeted delivery of antitumor agents can give them a “second life”. When developing new targeted drugs and their further introduction into clinical practice, the change in their pharmacodynamics and pharmacokinetics plays a special role. The paper describes a pharmacokinetic model of the targeted drug delivery. The conditions under which it is meaningful to search for a delivery vehicle for the active substance were described. Primary screening of antitumor agents was undertaken to modify them for the targeted delivery based on underlying assumptions of the model.https://www.siboncoj.ru/jour/article/view/517drugs directed transporttarget tissueantitumor drugs |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
A. V. Zaborovskiy K. G. Gurevich |
spellingShingle |
A. V. Zaborovskiy K. G. Gurevich MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION Sibirskij Onkologičeskij Žurnal drugs directed transport target tissue antitumor drugs |
author_facet |
A. V. Zaborovskiy K. G. Gurevich |
author_sort |
A. V. Zaborovskiy |
title |
MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION |
title_short |
MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION |
title_full |
MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION |
title_fullStr |
MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION |
title_full_unstemmed |
MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION |
title_sort |
modeling of targeted drug delivery part ii. multiple drug administration |
publisher |
Tomsk National Research Medical Center of the Russian Academy of Sciences |
series |
Sibirskij Onkologičeskij Žurnal |
issn |
1814-4861 2312-3168 |
publishDate |
2017-06-01 |
description |
In oncology practice, despite significant advances in early cancer detection, surgery, radiotherapy, laser therapy, targeted therapy, etc., chemotherapy is unlikely to lose its relevance in the near future. In this context, the development of new antitumor agents is one of the most important problems of cancer research. In spite of the importance of searching for new compounds with antitumor activity, the possibilities of the “old” agents have not been fully exhausted. Targeted delivery of antitumor agents can give them a “second life”. When developing new targeted drugs and their further introduction into clinical practice, the change in their pharmacodynamics and pharmacokinetics plays a special role. The paper describes a pharmacokinetic model of the targeted drug delivery. The conditions under which it is meaningful to search for a delivery vehicle for the active substance were described. Primary screening of antitumor agents was undertaken to modify them for the targeted delivery based on underlying assumptions of the model. |
topic |
drugs directed transport target tissue antitumor drugs |
url |
https://www.siboncoj.ru/jour/article/view/517 |
work_keys_str_mv |
AT avzaborovskiy modelingoftargeteddrugdeliverypartiimultipledrugadministration AT kggurevich modelingoftargeteddrugdeliverypartiimultipledrugadministration |
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1721263322279444480 |