MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA

MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA

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The search of molecular markers of metastasing and prognosis in prostate cancer remains an urgent task. In this study, we investigated the relationship of gene expression heparanase-1 (HPSE1) and D-glucuronil C5-epimerase (GLCE) with early disease relapse and metastasis of a 2,5−3 years after diagno...

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Main Authors: I. S. Kunin, M. M. Boboev, O. S. Kutsenko, L. A. Mostovich, S. V. Aidagulova, E. V. Grigorieva
Format: Article
Language:Russian
Published: ABV-press 2014-08-01
Series:Onkourologiâ
Subjects:
prostate adenocarcinoma
molecular markers for prostate cancer metastasis
heparanase-1
d-glucuronyl c5-epimerase
Online Access:https://oncourology.abvpress.ru/oncur/article/view/360
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spelling doaj-02c80368eec24979b004ffc49725504f2021-07-29T08:41:40ZrusABV-pressOnkourologiâ 1726-97761996-18122014-08-0184485210.17650/1726-9776-2012-8-4-48-52375MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMAI. S. Kunin0M. M. Boboev1O. S. Kutsenko2L. A. Mostovich3S. V. Aidagulova4E. V. Grigorieva5Novosibirsk state medical universityNovosibirsk regional clinicsInstitute of molecular biology and biophysics, Siberian Division of RAMS, NovosibirskInstitute of molecular biology and biophysics, Siberian Division of RAMS, NovosibirskNovosibirsk state medical universityInstitute of molecular biology and biophysics, Siberian Division of RAMS, NovosibirskThe search of molecular markers of metastasing and prognosis in prostate cancer remains an urgent task. In this study, we investigated the relationship of gene expression heparanase-1 (HPSE1) and D-glucuronil C5-epimerase (GLCE) with early disease relapse and metastasis of a 2,5−3 years after diagnosis. It was shown that the ratio of the expression levels of genes HPSE1/GLCE > 1 may serve as a prognostic relapse marker and trends of the tumour to metastasis. The data obtained suggest to use this option as a molecular marker for the diagnostics of metastatic process and the disease prognosis.https://oncourology.abvpress.ru/oncur/article/view/360prostate adenocarcinomamolecular markers for prostate cancer metastasisheparanase-1d-glucuronyl c5-epimerase
collection DOAJ
language Russian
format Article
sources DOAJ
author I. S. Kunin
M. M. Boboev
O. S. Kutsenko
L. A. Mostovich
S. V. Aidagulova
E. V. Grigorieva
spellingShingle I. S. Kunin
M. M. Boboev
O. S. Kutsenko
L. A. Mostovich
S. V. Aidagulova
E. V. Grigorieva
MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
Onkourologiâ
prostate adenocarcinoma
molecular markers for prostate cancer metastasis
heparanase-1
d-glucuronyl c5-epimerase
author_facet I. S. Kunin
M. M. Boboev
O. S. Kutsenko
L. A. Mostovich
S. V. Aidagulova
E. V. Grigorieva
author_sort I. S. Kunin
title MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
title_short MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
title_full MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
title_fullStr MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
title_full_unstemmed MOLECULAR MARKERS FOR METASTATIC PROSTATE ADENOCARCINOMA
title_sort molecular markers for metastatic prostate adenocarcinoma
publisher ABV-press
series Onkourologiâ
issn 1726-9776
1996-1812
publishDate 2014-08-01
description The search of molecular markers of metastasing and prognosis in prostate cancer remains an urgent task. In this study, we investigated the relationship of gene expression heparanase-1 (HPSE1) and D-glucuronil C5-epimerase (GLCE) with early disease relapse and metastasis of a 2,5−3 years after diagnosis. It was shown that the ratio of the expression levels of genes HPSE1/GLCE > 1 may serve as a prognostic relapse marker and trends of the tumour to metastasis. The data obtained suggest to use this option as a molecular marker for the diagnostics of metastatic process and the disease prognosis.
topic prostate adenocarcinoma
molecular markers for prostate cancer metastasis
heparanase-1
d-glucuronyl c5-epimerase
url https://oncourology.abvpress.ru/oncur/article/view/360
work_keys_str_mv AT iskunin molecularmarkersformetastaticprostateadenocarcinoma
AT mmboboev molecularmarkersformetastaticprostateadenocarcinoma
AT oskutsenko molecularmarkersformetastaticprostateadenocarcinoma
AT lamostovich molecularmarkersformetastaticprostateadenocarcinoma
AT svaidagulova molecularmarkersformetastaticprostateadenocarcinoma
AT evgrigorieva molecularmarkersformetastaticprostateadenocarcinoma
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