Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies
Premenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stre...
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doaj-02c5b16994a94449859519bdbb12547a2021-04-14T23:03:47ZengMDPI AGAntioxidants2076-39212021-04-011060460410.3390/antiox10040604Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional StudiesDominika Granda0Maria Karolina Szmidt1Joanna Kaluza2Institute of Human Nutrition Sciences, Warsaw University of Life Sciences—SGGW, 159C Nowoursynowska Str., 02-776 Warsaw, PolandInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences—SGGW, 159C Nowoursynowska Str., 02-776 Warsaw, PolandInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences—SGGW, 159C Nowoursynowska Str., 02-776 Warsaw, PolandPremenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stress are involved. This study aimed to systematically review case–control and cross-sectional studies investigating inflammation markers, oxidative stress, and antioxidant status among women with PMS and controls. The study protocol was registered with PROSPERO (no. CRD42020178545), and the authors followed the guidelines for performing a systemic review recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). By searching PubMed and Scopus databases (up to 8 January 2021), six case–control studies and five cross-sectional studies of medium or high quality were classified to the review. The systematic review included 652 women with PMS and 678 controls, for whom 36 eligible markers were determined. Limited evidence indicates increased levels of inflammatory parameters and suggests decreased antioxidant status in PMS women. Insufficient data with inconsistent results made it impossible to formulate a firm conclusion on the contribution of oxidative stress in PMS occurrence. To acknowledge the role of inflammation, oxidative stress, and antioxidant status in the pathophysiology of PMS, further research with case–control design and large study groups is needed.https://www.mdpi.com/2076-3921/10/4/604premenstrual syndromemenstruationoxidative stressinflammationantioxidantswomen |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dominika Granda Maria Karolina Szmidt Joanna Kaluza |
spellingShingle |
Dominika Granda Maria Karolina Szmidt Joanna Kaluza Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies Antioxidants premenstrual syndrome menstruation oxidative stress inflammation antioxidants women |
author_facet |
Dominika Granda Maria Karolina Szmidt Joanna Kaluza |
author_sort |
Dominika Granda |
title |
Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies |
title_short |
Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies |
title_full |
Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies |
title_fullStr |
Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies |
title_full_unstemmed |
Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies |
title_sort |
is premenstrual syndrome associated with inflammation, oxidative stress and antioxidant status? a systematic review of case-control and cross-sectional studies |
publisher |
MDPI AG |
series |
Antioxidants |
issn |
2076-3921 |
publishDate |
2021-04-01 |
description |
Premenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stress are involved. This study aimed to systematically review case–control and cross-sectional studies investigating inflammation markers, oxidative stress, and antioxidant status among women with PMS and controls. The study protocol was registered with PROSPERO (no. CRD42020178545), and the authors followed the guidelines for performing a systemic review recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). By searching PubMed and Scopus databases (up to 8 January 2021), six case–control studies and five cross-sectional studies of medium or high quality were classified to the review. The systematic review included 652 women with PMS and 678 controls, for whom 36 eligible markers were determined. Limited evidence indicates increased levels of inflammatory parameters and suggests decreased antioxidant status in PMS women. Insufficient data with inconsistent results made it impossible to formulate a firm conclusion on the contribution of oxidative stress in PMS occurrence. To acknowledge the role of inflammation, oxidative stress, and antioxidant status in the pathophysiology of PMS, further research with case–control design and large study groups is needed. |
topic |
premenstrual syndrome menstruation oxidative stress inflammation antioxidants women |
url |
https://www.mdpi.com/2076-3921/10/4/604 |
work_keys_str_mv |
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