Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies

Premenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stre...

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Main Authors: Dominika Granda, Maria Karolina Szmidt, Joanna Kaluza
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/10/4/604
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spelling doaj-02c5b16994a94449859519bdbb12547a2021-04-14T23:03:47ZengMDPI AGAntioxidants2076-39212021-04-011060460410.3390/antiox10040604Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional StudiesDominika Granda0Maria Karolina Szmidt1Joanna Kaluza2Institute of Human Nutrition Sciences, Warsaw University of Life Sciences—SGGW, 159C Nowoursynowska Str., 02-776 Warsaw, PolandInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences—SGGW, 159C Nowoursynowska Str., 02-776 Warsaw, PolandInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences—SGGW, 159C Nowoursynowska Str., 02-776 Warsaw, PolandPremenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stress are involved. This study aimed to systematically review case–control and cross-sectional studies investigating inflammation markers, oxidative stress, and antioxidant status among women with PMS and controls. The study protocol was registered with PROSPERO (no. CRD42020178545), and the authors followed the guidelines for performing a systemic review recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). By searching PubMed and Scopus databases (up to 8 January 2021), six case–control studies and five cross-sectional studies of medium or high quality were classified to the review. The systematic review included 652 women with PMS and 678 controls, for whom 36 eligible markers were determined. Limited evidence indicates increased levels of inflammatory parameters and suggests decreased antioxidant status in PMS women. Insufficient data with inconsistent results made it impossible to formulate a firm conclusion on the contribution of oxidative stress in PMS occurrence. To acknowledge the role of inflammation, oxidative stress, and antioxidant status in the pathophysiology of PMS, further research with case–control design and large study groups is needed.https://www.mdpi.com/2076-3921/10/4/604premenstrual syndromemenstruationoxidative stressinflammationantioxidantswomen
collection DOAJ
language English
format Article
sources DOAJ
author Dominika Granda
Maria Karolina Szmidt
Joanna Kaluza
spellingShingle Dominika Granda
Maria Karolina Szmidt
Joanna Kaluza
Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies
Antioxidants
premenstrual syndrome
menstruation
oxidative stress
inflammation
antioxidants
women
author_facet Dominika Granda
Maria Karolina Szmidt
Joanna Kaluza
author_sort Dominika Granda
title Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies
title_short Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies
title_full Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies
title_fullStr Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies
title_full_unstemmed Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies
title_sort is premenstrual syndrome associated with inflammation, oxidative stress and antioxidant status? a systematic review of case-control and cross-sectional studies
publisher MDPI AG
series Antioxidants
issn 2076-3921
publishDate 2021-04-01
description Premenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stress are involved. This study aimed to systematically review case–control and cross-sectional studies investigating inflammation markers, oxidative stress, and antioxidant status among women with PMS and controls. The study protocol was registered with PROSPERO (no. CRD42020178545), and the authors followed the guidelines for performing a systemic review recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). By searching PubMed and Scopus databases (up to 8 January 2021), six case–control studies and five cross-sectional studies of medium or high quality were classified to the review. The systematic review included 652 women with PMS and 678 controls, for whom 36 eligible markers were determined. Limited evidence indicates increased levels of inflammatory parameters and suggests decreased antioxidant status in PMS women. Insufficient data with inconsistent results made it impossible to formulate a firm conclusion on the contribution of oxidative stress in PMS occurrence. To acknowledge the role of inflammation, oxidative stress, and antioxidant status in the pathophysiology of PMS, further research with case–control design and large study groups is needed.
topic premenstrual syndrome
menstruation
oxidative stress
inflammation
antioxidants
women
url https://www.mdpi.com/2076-3921/10/4/604
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AT joannakaluza ispremenstrualsyndromeassociatedwithinflammationoxidativestressandantioxidantstatusasystematicreviewofcasecontrolandcrosssectionalstudies
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