Lentiviral-mediated RNAi targeting caspase-3 inhibits apoptosis induced by serum deprivation in rat endplate chondrocytes in vitro

Lentiviral-mediated RNAi targeting caspase-3 inhibits apoptosis induced by serum deprivation in rat endplate chondrocytes in vitro

Current studies find that degenerated cartilage endplates (CEP) of vertebrae, with fewer diffusion areas, decrease nutrient supply and accelerate intervertebral disc degeneration. Many more apoptotic cells have been identified in degenerated than in normal endplates, and may be responsible for the d...

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Bibliographic Details
Main Authors: L. Ding, J.P. Wu, G. Xu, B. Zhu, Q.M. Zeng, D.F. Li, W. Lu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2014-06-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Cartilaginous endplate
Chondrocytes
RNA interference
Apoptosis
Caspase-3
Serum deprivation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600445&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600445&lng=en&tlng=en

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