Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain

Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain

Cellular entry of diphtheria toxin is a multistage process involving receptor targeting, endocytosis, and translocation of the catalytic domain across the endosomal membrane into the cytosol. The latter is ensured by the translocation (T) domain of the toxin, capable of undergoing conformational ref...

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Bibliographic Details
Main Authors: Alexey S. Ladokhin, Mauricio Vargas-Uribe, Mykola V. Rodnin, Chiranjib Ghatak, Onkar Sharma
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Toxins
Subjects:
membrane translocation
pH-dependent refolding
bilayer insertion
tryptophan fluorescence
depth-dependent fluorescence quenching
Online Access:https://www.mdpi.com/2072-6651/9/10/299

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