Pichia pastoris-expressed dengue 2 envelope forms virus-like particles without pre-membrane protein and induces high titer neutralizing antibodies.

Pichia pastoris-expressed dengue 2 envelope forms virus-like particles without pre-membrane protein and induces high titer neutralizing antibodies.

Dengue is a mosquito-borne viral disease with a global prevalence. It is caused by four closely-related dengue viruses (DENVs 1-4). A dengue vaccine that can protect against all four viruses is an unmet public health need. Live attenuated vaccine development efforts have encountered unexpected inter...

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Bibliographic Details
Main Authors: Shailendra Mani, Lav Tripathi, Rajendra Raut, Poornima Tyagi, Upasana Arora, Tarani Barman, Ruchi Sood, Alka Galav, Wahala Wahala, Aravinda de Silva, Sathyamangalam Swaminathan, Navin Khanna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717637/?tool=EBI

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