Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells

Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells

Human mast cells (MCs) contain TG-rich cytoplasmic lipid droplets (LDs) with high arachidonic acid (AA) content. Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for eicosanoid generation by activated human primary MCs...

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Bibliographic Details
Main Authors: Andrea Dichlberger, Stefanie Schlager, Katariina Maaninka, Wolfgang J. Schneider, Petri T. Kovanen
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
leukotrienes
lipid droplets
lipolysis and fatty acid metabolism
phospholipases/A2
prostaglandins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520366876

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http://www.sciencedirect.com/science/article/pii/S0022227520366876

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