LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients

LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients

Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribut...

Full description

Bibliographic Details
Main Authors:	Lorenzo Islas-Vazquez, Heriberto Prado-Garcia, Dolores Aguilar-Cazares, Manuel Meneses-Flores, Miriam Galicia-Velasco, Susana Romero-Garcia, Catalina Camacho-Mendoza, Jose Sullivan Lopez-Gonzalez
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2015/430943

Similar Items

TGF-β induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction.
by: Takatoku Oida, et al.
Published: (2010-11-01)

Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes
by: Ying-zhong Lin, et al.
Published: (2013-01-01)

Mechanisms of action of CD109, a novel TGF-beta co-receptor
by: Bizet, Albane
Published: (2011)

CD105 expression and its effects on TGF-beta signalling, angiogenesis and cell behaviour
by: Guo, Baoqiang
Published: (2003)

MECHANISMS OF TGF BETA-INDUCED INHIBITION OF CD1D-MEDIATED ANTIGEN PRESENTATION
by: Ryan, Jennifer Carrie
Published: (2011)

Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation.
by: Jorieke H Peters, et al.
Published: (2008-01-01)

HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta.
by: Caroline H T Hall, et al.
Published: (2010-08-01)

PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs
by: Leticia Tordesillas, et al.
Published: (2018-12-01)

Expression of PD-1 by CD4+CD25+CD127low Treg cells in the peripheral blood of lung cancer patients
by: Zhong AY, et al.
Published: (2015-07-01)

TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells.
by: Mohamed Elrefaei, et al.
Published: (2009-12-01)

An investigation into the role of LAP+CD8+ T cells in the chronic hepatitis C patients
by: Kai Sheng Ko, et al.
Published: (2012)

CD4+ CD25+ regulatory T cells promote hepatocellular carcinoma invasion via TGF-β1-induced epithelial–mesenchymal transition
by: Shi C, et al.
Published: (2018-12-01)

Regulation of CD4 T Cell Responses to IL-7 by IFN-alpha and TGF-beta in Treated HIV Disease
by: Nguyen, Thao
Published: (2017)

Astragalus Oral Solution Ameliorates Allergic Asthma in Children by Regulating Relative Contents of CD4+CD25highCD127low Treg Cells
by: Wei Wang, et al.
Published: (2018-09-01)

CD4+CD25+CD127-Foxp3+ and CD8+CD28- Tregs in Renal Transplant Recipients: Phenotypic Patterns, Association With Immunosuppressive Drugs, and Interaction With Effector CD8+ T Cells and CD19+IL-10+ Bregs
by: Mostafa G. Aly, et al.
Published: (2021-07-01)

CD3+CD4+LAP+Foxp3-Regulatory Cells of the Colonic Lamina Propria Limit Disease Extension in Ulcerative Colitis
by: Alessia Butera, et al.
Published: (2018-10-01)

Effect of CD109, a novel TGF-beta antagonist, in a skin flap-induced hypoxic wound model
by: Winocour, Sebastian
Published: (2011)

In vivo dynamical interactions between CD4 Tregs, CD8 Tregs and CD4+ CD25- cells in mice.
by: Arnon Arazi, et al.
Published: (2009-01-01)

Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes
by: Marcin Moniuszko, et al.
Published: (2013-01-01)

Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphoma
by: Hyo Jin Kim, et al.
Published: (2021-07-01)

TGF-β: Many Paths to CD103<sup>+</sup> CD8 T Cell Residency
by: Zhijuan Qiu, et al.
Published: (2021-04-01)

Binding of TGF- ?1 latency-associated peptide (LAP) to ???6 integrin modulates behaviour of squamous carcinoma cells
by: Thomas, G.J, et al.
Published: (2002)

Increased Circulating Th17 but Decreased CD4+Foxp3+ Treg and CD19+CD1dhiCD5+ Breg Subsets in New-Onset Graves’ Disease
by: Jing Qin, et al.
Published: (2017-01-01)

TGF-beta signaling at the cellular junctions
by: Dudu, Veronica
Published: (2005)

Involvement of TGF-beta in skin photoaging
by: Choi, Won Seon, 1975-
Published: (2008)

Evaluation of CD44 and TGF-B Expression in Oral Carcinogenesis
by: Narges Ghazi, et al.
Published: (2021-03-01)

Low frequency of CD4<sup>+</sup>CD25<sup>+ </sup>Treg in SLE patients: a heritable trait associated with <it>CTLA4 </it>and <it>TGFβ </it>gene variants
by: Viana João F, et al.
Published: (2009-01-01)

Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.
by: Zheng-Feng Zhu, et al.
Published: (2014-01-01)

Lap-Robotics
Published: (2015-01-01)

In the Lap of Lincoln
by: Steeber, Dawson B.
Published: (2008)

TGFβ Is Specifically Upregulated on Circulating CD14++ CD16+ and CD14+ CD16++ Monocytes in Patients with Atrial Fibrillation and Severe Atrial Fibrosis
by: David Heinzmann, et al.
Published: (2018-08-01)

Studies on the Dynamic Analysis and the Lapping Tracks in the Ball-Lapping Systems
by: Yih-chyun Hwang, et al.
Published: (2006)

CD4+CD25highCD127- regulatory T-cells in COPD: smoke and drugs effect
by: Alessandra Chiappori, et al.
Published: (2016-01-01)

CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung
by: Xueyan ePeng, et al.
Published: (2014-05-01)

Subset- and Antigen-Specific Effects of Treg on CD8+ T Cell Responses in Chronic HIV Infection.
by: Maria Nikolova, et al.
Published: (2016-11-01)

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine
by: C. C. Bain, et al.
Published: (2017-09-01)

Overexpression of NNT-AS1 Activates TGF-β Signaling to Decrease Tumor CD4 Lymphocyte Infiltration in Hepatocellular Carcinoma
by: Yakun Wang, et al.
Published: (2020-01-01)

Data on the TGFβ response of CD4+ T cells in the absence of Eed
by: Taku Naito, et al.
Published: (2018-04-01)

The role of Notch and TGF-β pathways in CD4+ T cell responses
by: Corsin-Jimenez, Marta
Published: (2002)

CD4+CD25+CD127low FoxP3+ regulatory T cells in Crohn’s disease
by: Khalili Ali, et al.
Published: (2018-09-01)