Imaging alterations of cardiomyocyte cAMP microdomains in disease

• Main Authors: Alexander eFroese, Viacheslav eNikolaev
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2015-08-01
• Series: Frontiers in Pharmacology
• Subjects: Heart Failure; Hypertrophy; cardiomyocyte; biosensor; cAMP; FRET
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00172/full

3’,5’-cyclic adenosine monophosphate (cAMP) is an important second messenger which regulates heart function by acting in distinct subcellular microdomains. Recent years have provided deeper mechanistic insights into compartmentalized cAMP signaling and its link to cardiac disease. In this mini review, we summarize newest developments in this field achieved by cutting-edge biochemical and biophysical techniques. We further compile the data from different studies into a bigger picture of so far uncovered alterations in cardiomyocyte cAMP microdomains which occur in compensated cardiac hypertrophy and chronic heart failure. Finally, future research directions and translational perspectives are briefly discussed.