Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

Accumulating evidence suggest that cerebral microvascular disease increases with advancing age and is associated with lacunar stroke, leukoaraiosis, vascular dementia and Alzheimer disease. Increased blood brain barrier (BBB) permeability/leakage takes “center stage” in ongoing age-related vascular/...

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Bibliographic Details
Main Authors:	Svetlana M. Stamatovic, Gabriela Martinez-Revollar, Anna Hu, Jennifer Choi, Richard F. Keep, Anuska V. Andjelkovic
Format:	Article
Language:	English
Published:	Elsevier 2019-06-01
Series:	Neurobiology of Disease
Subjects:	Blood-brain barrier Permeability Aging Tight junction Sirtuin-1
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996118305552

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